Detección de Helicobacter pylori y caracterización del la región -31 del gen de la Interleucina 1-？ humana en pacientes de una población colombiana con enfermedades gastroduodenales

the aim of this study was to investigate the presence of helicobacter pylori and interleukin 1-β genotyping (il-1b -31), to determine the relationship between one polymorphism in the -31 region of interleukin 1-β gene and the severity of the clinical manifestations. gastric biopsies from 71 patients were submitted to histopathological examination and genotyped by molecular methods (pcr y pcr-rflp). the results indicated that 97.2% of the patients have alterations in the gastric mucosa, the presence of h. pylori was demonstrated in 44 patients and tt, ct and cc genotypes were detected in 12.7%, 60.6% and 26.8%, respectively. il-1b genotypes were not associated with the severity of gastric mucosal damage in the studied population.