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Secondary Mapping of Lymphatic Filariasis in Haiti-Definition of Transmission Foci in Low-Prevalence Settings

DOI: 10.1371/journal.pntd.0001807

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Abstract:

To eliminate Lymphatic filariasis (LF) as a public health problem, the World Health Organization (WHO) recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia) should receive mass drug administration (MDA) of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (<1%) are thought to pose little risk for continued transmission of LF. Five low-antigen prevalence communes in Haiti, characterized as part of a national survey, were further assessed for transmission in this study. An initial evaluation of schoolchildren was performed in each commune to identify antigen-positive children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS) coordinates and immunochromatographic tests (ICT) for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission.

References

[1]  Hotez P, Bottazzi M, Franco-Paredes C, Ault S, Periago M, et al. (2008) The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Neglected Tropical Diseases 2: e300. doi: 10.1371/journal.pntd.0000300
[2]  CDC (1993) Recommendations of the International Task Force for Disease Erradication. MMWR 42: 25.
[3]  WHO (2011) Global Programme to Eliminate Lymphatic Filaraisis: progress report on mass drug administration, 2010. Geneva: World Health Organization. 12 p.
[4]  Weil G, Ramzy R (2007) Diagnostic tools for filariasis elimination programs. TRENDS in Parasitology 23: 5. doi: 10.1016/j.pt.2006.11.002
[5]  WHO (2000) Operational guidelines for rapid mapping of Bancroftian filariasis in Africa. Geneva. 17 p.
[6]  Vanamail P, Subramanian S, Srividya A, Ravi R, Krishnamoorthy K, et al. (2006) Operational feasibility of lot quality assurance sampling (LQAS) as a tool in routine process monitoring of filariasis control programmes. Tropical medicine & international health : TM & IH 11: 1256–1263.
[7]  PAHO (2009) Epidemiological Profiles of Neglected Diseases and other Infections Related to Poverty in Latin America and the Caribbean. Washington, DC: Pan American Health Organization. 123 p.
[8]  Beau de Rochars M, Milford M, Jean Y, Desormeaux A, Dorvil J, et al. (2004) Geographic distribution of lymphatic filariasis in Haiti. American Journal of Tropical Medicine and Hygeine 71: 4.
[9]  Kulldorff M (1999) An Isotonic Spatial Scan for Geographical Disease Surveillance. Journal of the National Institute of Public Health 24: 7.
[10]  Raccurt CP (1999) [Lymphatic filarisais in Haiti: a century of history]. Bull Soc Pathol Exot 92: 6.
[11]  Leite A, de Lima A, Leite R, Santos R, Gon?alves J, et al. (2010) Assessment of family and neighbors of an individual infected with Wuchereria bancrofti from a non-endemic are in the city of Maceió, Brazil. Brazilian Journal of Infectious Disease 14: 4.
[12]  Washington C, Radday J, Streit T, Boyd H, Beach M, et al. (2004) Spatial clustering of filarial transmission before and after a mass drug administration in a setting of low infection prevalence. Filaria Journal 3: 14.
[13]  Joseph H, Moloney J, McClintock S, Lammie P, Melrose W (2011) First evidence of spatial clustering of lymphatic filariasis in Aedes polynesiensis endemic area. Acta Tropica 120S: 9.
[14]  Braga C, Dourado M, Ximenes A, Alves L, Brayner F, et al. (2003) Field evaluation of the whole blood immunochromatographic test for rapid Bancroftian filariasis diagnosis in the Northeast of Brazil. Rev Inst Med trop S Paulo 45: 5. doi: 10.1590/S0036-46652003000100002
[15]  Talbot JT, Viall A, Direny A, de Rochars MB, Addiss D, et al. (2008) Predictors of Compliance in Mass Drug Administration for the Treatment and Prevention of Lymphatic Filariasis in Leogane, Haiti. The American Journal of Tropical Medicine and Hygiene 78: 283–288.
[16]  Mathieu E, Direny AN, De Rochars MB, Streit TG, Addiss DG, et al. (2006) Participation in three consecutive mass drug administrations in Leogane, Haiti. Participations lors de trois administrations massives de médicament à Leogane en Ha?ti. Participación en tres administraciones masivas de medicamentos consecutivas en Leogane, Haiti. Tropical Medicine & International Health 11: 862–868. doi: 10.1111/j.1365-3156.2006.01626.x
[17]  Boyd A, Won K, McClintock S, Donovan C, Laney S, et al. (2010) A community-based study of factors associated with continuing transmission of lymphatic filariasis in Leogane, Haiti. PLoS Neglected Tropical Diseases 4: e640. doi: 10.1371/journal.pntd.0000640
[18]  Huppatz C, Durrheim D, Lammie P, Kelly P, Melrose W (2008) Eliminating lymphatic filariasis-the surveillance challange. Tropical Medicine & International Health 13: 3.
[19]  Lammie P, Weil G, Rahmah N, Kaliraj P, Steel C, et al. (2004) Recombinant antigen-based antibody assays for the diagnosis and surveillance of lymphatic filariasis-a multicenter trail. Filaria Journal 3: 5. doi: 10.1186/1475-2883-3-5
[20]  Ramaiah K, Thiruvengadam B, Vanamail P, Subramanian S, Gunasekaran S, et al. (2009) Prolonged persistence of residual Wuchereria bancrofti infection after cessation of diethylcarbamazine-fortified salt programme. Tropical Medicine & International Health 14: 870–876. doi: 10.1111/j.1365-3156.2009.02307.x

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