vasculitis is a pleomorfic inflammatory syndrome that involves mainly the wall of blood vessels. the hepatitis c virus infection may be associated to extra-hepatic manifestations, including autoimmune diseases. two forms of vasculitis have been associated to hepatitis c virus, namely: mixed cryoglobulinemia and polyarteritis nodosa. the diagnosis and the therapeutic management of these conditions are clinical challenges. there are few data available in the literature about the antiviral treatment efficacy in patients with hepatitis c virus and autoimmune diseases. we describe an unusual patient displaying vasculitis of small vessels and with hepatitis c virus infection.