introduction: tuberculosis does not present good health indicators in the republic of the guinea-bissau, like most other developing countries. objective: to study the epidemiological status of the illness in the 2000-2005 period in the republic of the guinea-bissau and its provinces. method: secondary data were collected from the national fight against leprosy and tuberculosis program, in the period from 2000 to 2005, and annual reports of the capital and the provinces were analyzed to calculate coefficients and indicators. results: the number of tuberculosis cases remained stable in the period from 2000 (1,959 cases) to 2005 (1,888 cases). the percentage of pulmonary cases ranged from 96.0 to 98.8%, of which 55% had positive smears. the coefficients of prevalence, incidence and mortality, in 2005 were 142.4/100,000, 131.3/100,000 and 16.8/100,000 inhabitants, respectively. the main concentration of cases occurred in the region of the capital. cure rates varied between 46.5% in 2000 and 69.6% in 2005 and treatment interruption rates were 29.8% in 2000 and 12.1% in 2005. conclusion: the indicators of the national strategic plan must improve, particularly with regard to active case search, decentralization of patient care, implementation of the dots strategy, and the need for an efficient information and reporting system.