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Síntese e determina??o da atividade antimicrobiana de derivados 5-nitro-2-tiofilidênicos frente a Staphylococcus aureus multi-resistente

DOI: 10.1590/S1516-93322006000300016

Keywords: staphylococcus aureus, synthesis, mic, nifuroxazide, multidrug-resistance.

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Abstract:

infection diseases caused by methicillin-resistant staphylococcus aureus have been an increasing problem worldwide presenting significant morbidity and mortality rates. thus, fourteen benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized and tested against standard (atcc 25923) and multidrug-resistant strains of staphylococcus aureus. all compounds exhibited significant bacteriostatic activity and, in such cases, also bactericidal activity, especially the p-coch3 derivative with mic = 0.14 mg/ml. the results have demonstrated the potential of synthesized compounds as alternative to the development of selective antimicrobial agents.

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