infection diseases caused by methicillin-resistant staphylococcus aureus have been an increasing problem worldwide presenting significant morbidity and mortality rates. thus, fourteen benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazides were designed, synthesized and tested against standard (atcc 25923) and multidrug-resistant strains of staphylococcus aureus. all compounds exhibited significant bacteriostatic activity and, in such cases, also bactericidal activity, especially the p-coch3 derivative with mic = 0.14 mg/ml. the results have demonstrated the potential of synthesized compounds as alternative to the development of selective antimicrobial agents.
