Purpose/Hypothesis: Parkinson’s disease (PD) is a progressive, neurodegenerative disorder characterized by both motor and non-motor symptoms. The motor symptoms comprise bradykinesia, rigidity, tremor, and postural instability. The non-motor symptoms may include anxiety, depression, and cognitive impairment. As the disease advances, PD symptoms also progress, leading to deterioration in physical, mental, and cognitive function. Mounting evidence shows that aerobic exercise may boost neuroplasticity in aging adults and patients with PD. Thus, the purpose of this systematic review was to examine the effects of aerobic exercise on motor, mental, and cognitive impairments in people with PD. Materials and Methods: Five databases (PubMed, CINAHL, Medline Complete, Cochrane Library, and Google Scholar) were systematically searched. To be eligible for inclusion, the study must have: 1) enrolled participants with idiopathic PD, 2) administered aerobic exercise as an intervention, (3) compared aerobic exercise with no exercise/other exercise, (4) measured motor, mental, and cognitive functions, and (5) used a randomized controlled design. The Physiotherapy Evidence Database (PEDro) scale was applied to assess the methodological quality of each trial. Results: Eight studies were included in this review, with a sample size of 507 patient participants. PEDro scores ranged from 5/10 to 9/10, indicating a fair to strong quality of the trials. Motor severity was assessed using the Unified PD Rating Scale-III. Significant between-group differences were reported in four of seven studies in favor of aerobic exercise (p < 0.05). Five trials found significant between-group differences in mental function favoring aerobic training (p < 0.01). Among the seven trials that assessed cognitive function, significant between-group differences (P < 0.05) were observed in three studies. The results were in support of the aerobic exercise program. Conclusions: Findings of this review study suggest that aerobic exercise improves physical, mental, and cognitive function in patients with PD. Aerobic exercise may stimulate neuroplasticity and facilitate cognitive control networks in PD. More research is needed to expand the evidence on this topic to guide treatment for this patient population. Clinical Relevance: Patients with PD may benefit from aerobic exercise for improved function in several domains. Integrating aerobic exercise with the clinical management of PD can be pivotal for enhancing the quality of life in people living with PD.
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