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-  2019 

Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway

DOI: 10.1177/1533033819849068

Keywords: macrophage, M2 polarization, colon cancer cell, EGF/EGFR, PI3K/AKT/mTOR pathway

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Abstract:

Tumor environment has been recognized to affect cancer cell progression, such as tumor-associated macrophages. However, increasing evidences suggest that tumor cells are capable of regulating polarization of tumor-associated macrophages. In this study, we investigate the mechanism of how colon cancer cell impacts tumor-associated macrophages polarization

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