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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2

DOI: 10.1038/s41420-019-0189-z

Keywords: Innate immunity, Apoptosis

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Abstract:

a [Cr51]-labeled MCA102 (circle), MCA102 E1A (triangle) cells were incubated with RNK-16 cells at the indicated RNK:target ratios in the absence or presence (inverted triangle) of 100?μM zVAD-fmk. After 6?h, supernatants were collected and % specific Cr51 release was assessed (mean?±?SEM; n?=?4, ***P?<?0.0001, **P?≤?0.0084, one-way ANOVA). b [Cr51]-labeled BMK (circle) or BMK-E1A (triangle) cells were incubated with RNK-16 cells at the indicated RNK:target ratios in the absence or presence (inverted triangle) of 100?μM zVAD-fmk. After 6?h, supernatants were collected and % specific Cr51 release was assessed (mean?±?SEM; n?=?4, ***P?≤?0.0001, one-way ANOVA

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