|
- 2019
E1A oncogene induced sensitization to NK cell induced apoptosis requires PIDD and Caspase-2DOI: 10.1038/s41420-019-0189-z Keywords: Innate immunity, Apoptosis Abstract: a [Cr51]-labeled MCA102 (circle), MCA102 E1A (triangle) cells were incubated with RNK-16 cells at the indicated RNK:target ratios in the absence or presence (inverted triangle) of 100?μM zVAD-fmk. After 6?h, supernatants were collected and % specific Cr51 release was assessed (mean?±?SEM; n?=?4, ***P?<?0.0001, **P?≤?0.0084, one-way ANOVA). b [Cr51]-labeled BMK (circle) or BMK-E1A (triangle) cells were incubated with RNK-16 cells at the indicated RNK:target ratios in the absence or presence (inverted triangle) of 100?μM zVAD-fmk. After 6?h, supernatants were collected and % specific Cr51 release was assessed (mean?±?SEM; n?=?4, ***P?≤?0.0001, one-way ANOVA
|