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Identification and Preclinical Evaluation of the Bicyclic
Pyrimidine γ-Secretase Modulator BMS-932481
DOI: 10.1021/acsmedchemlett.8b00541
Arvind Mathur, Ashok Trehan, Catherine R. Burton, Charles F. Albright, Daniel Smith, Dmitry S. Zuev, James E. Grace, Jason M. Guernon, Jere E. Meredith, Jeremy H. Toyn, Jianliang Shi, Jianqing Li, John E. Macor, John S. Morrison, Kenneth M. Boy, Kimberley A. Lentz, Lawrence R. Marcin, Li Xu, Lorin A. Thompson, Mendi A. Higgins, Michael K. Ahlijanian, Rex Denton, Richard E. Olson, S. Roy Kimura, Subramaniam Krishnananthan, Tatyana Zvyaga, Xiaoliang Zhuo, Yong-Jin Wu, Yunhui Zhang
Keywords: Alzheimer’s disease, clinical candidate, gamma-secretase modulator, bicyclic pyrimidine
Abstract:
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