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ISSN: 2333-9721
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Identification and Structure-Guided Development of
Pyrimidinone Based USP7 Inhibitors
DOI: 10.1021/acsmedchemlett.7b00512
Caroline Hughes, Colin R. O’Dowd, Eamon Cassidy, Elias Arkoudis, Ewa Odrzywol, Ewelina Rozycka, Gerald Gavory, Hugues Miel, J. S. Shane Rountree, Jakub T. Flasz, Keeva McClelland, Linda Jordan, Matthew D. Helm, Natalie Page, Oliver Barker, Peter R. Hewitt, Scarlett Dvorkin, Stephanie Feutren-Burton, Timothy Harrison
Keywords: USP7, ubiquitination, deubiquitinase, HAUSP, p53, Mdm2, proteasome, ubiquitin
Abstract:
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