Synthesis and Spectral Characterization of Novel 2, 3-Disubstituted Quinazolin-4(3H) one Derivatives

New series of 2,3-disubstituted quinazolin-4(3H)- one were synthesized via the reaction of the readily obtainable 2-thioxo-3-phenyl-quinazolin-4(3H)one 1 with ethyl chloroacetate followed by hydrazinolysis to afford the hydrazide 3 which allowed to react with different electrophilic reagents such as carbon disulphide, phenyl isothiocyanate, β-diketones, anhydrides, acrylonitrile, ethyl cinnamate, dimethyl acetylene dicarboxylate, aldehydes, arylidene malononitrile and lauroyl chloride. Some of the newly synthesized compounds showed promising anti-inflammatory activity.