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Utility of Activated Nitriles in the Synthesis of Some New Heterocyclic Compounds

DOI: 10.5923/j.ajoc.20120202.06

Keywords: Cyanoacetamide, Cyanoketen N,S-acetal derivative, Enaminonitrile, 1,3-Dithiolane derivative

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Abstract:

New 4-(2-cyanoacetamido)benzoic acid (1) was utilized as key intermediate for the synthesis of some new thiazole, pyrazole, oxazole, pyrimidine, 1,3-dithiolane, thiophene, coumarin, oxazine and pyridazine derivatives. Newly synthesized compounds were characterized by elemental analyses and spectral data (IR, 1H NMR and mass spectra).

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