Titanium Reagents in Heterocyclic Synthesis

This review confronts the diversity and selectivity of titanium reagents that mediate heterocyclic synthesis. Applications of different titanium based reagents in various organic reactions leading to the formation of heterocyclic compounds are discussed. Among others, epoxide-opening arene annulations, intramolecular coupling of carbonyl groups intermolecular hydroamination, intramolecular aza-Heck, regioselective synthesis of indoles, anti-Markovnikov hydration of internal and terminal alkynes, and the synthesis of polyarylpyrroles under microwave conditions, are reviewed.