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Modelo de estudio mediante microPET para la evaluación del metabolismo glucolítico en el miocardio de rata con 18F-FDG: Experiencia inicial en México

Keywords: 18f-fdg, micropet, myocardial viability.

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Abstract:

purpouse: to standarize an acquisition protocol for the study of myocardial metabolism in adult rats. material and methods: three wistar adult male rats were studied in three different protocols: no fasting group, fasting group over a period of 12 hr before the study with only water provided ad libitum, and fasting group by the same time receiving an oral 50% glucose solution. thirty-minute acquisition images were obtained with a micro-pet, thirty and sixty minutes after the administration of 370 - 555 mbq 18f-fdg. comparative and visual analysis were performed by two experts in the field. results: eigtheen studies were analyzed, six per group. the best images were those of the fist group, especially those taken at 60 minutes after the 18f-fdg administration. conclusion: it is possible to establish the non-fasting protocol for the assessment of myocardial metabolism to be used in the future for the myocardial viability evaluation in ischemic cardiopathy.

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