Tratamento da disforia pré-menstrual com antidepressivos: revis？o dos ensaios clínicos controlados

intoduction: premenstrual dysphoria (pmd), which affects between 3% and 8% of women during reproductive years, represents a more severe type of premenstrual syndrome. mood and behavior changes are predominant in pmd. it is believed that there is some kind of link between pms and mood disorders. objective: studying the efficacy of antidepressants in pmd. methods: we elaborated a review of controlled clinical trials with antidepressants in the treatment of pmd, using the following databases: medline, lilacs, psycinfo and cochrane library. results: clomipramine, fluoxetine, sertraline, paroxetine and venlafaxine were superior to placebo in various studies. discussion: women with pmd possibly present a serotonergic dysfunction. conclusion: some antidepressants, specialy ssris, seem to be effective in the treatment of pmd.