Factores inmunológicos y microbiológicos asociados con la etiología de la estomatitis aftosa recurrente

recurrent aphtous stomatitis (ras) is a common, painful and ulcerative disorder of the oral cavity of unknown etiology. several reports have suggested that the patients affected with this condition have a defectous celular immune response. aditionally, adhesion molecules are known to play a crucial role in the recruitment of immflamatory cells to sites of inflammation. adhesion molecules vcam-1 (vascular cell adhesion molecule-1), and icam-1 (intercellular adhesion molecule-1) are essential for the binding of inflammatory cells to endothelial cells. circulating forms of these molecules have been detected in a number of vasculitic disease. ras has some features of a vasculitic disease process. helicobacter pylori has been shown to be the causative factor in peptic ulcers, which is very similar with ras the aim of this study was to review the inmmunological and microbiological factors associated with the etiology of ras.