|
|
血液标志物对预测重症急性胰腺炎继发ARDS的应用进展
|
Abstract:
重症急性胰腺炎(SAP)是急性胰腺炎(AP)最严重的类型，具有发病迅速、病情危重、进展快等特点。并发急性呼吸窘迫综合征(ARDS)时显著增加了病死率。早期识别并发ARDS高风险患者是降低病死率的关键，本文旨在系统回顾血液标志物对预测SAP合并ARDS的研究进展，为临床早期识别和干预提供依据。
Severe acute pancreatitis (SAP), the most critical form of acute pancreatitis (AP), is characterized by abrupt onset, severe progression, and rapid deterioration. The development of acute respiratory distress syndrome (ARDS) significantly increases mortality. Early identification of high-risk patients prone to ARDS is crucial for reducing fatality rates. This article systematically reviews research advances in blood-based biomarkers for predicting ARDS in SAP, aiming to provide a foundation for early clinical recognition and intervention.
| [1] | 中华医学会外科学分会胰腺外科学组. 中国急性胰腺炎诊治指南(2021) [J]. 浙江实用医学, 2021, 26(6): 511-519, 535. |
| [2] | Mederos, M.A., Reber, H.A. and Girgis, M.D. (2021) Acute Pancreatitis. JAMA, 325, 382-390. https://doi.org/10.1001/jama.2020.20317 |
| [3] | Schepers, N.J., Bakker, O.J., Besselink, M.G., Ahmed Ali, U., Bollen, T.L., Gooszen, H.G., et al. (2018) Impact of Characteristics of Organ Failure and Infected Necrosis on Mortality in Necrotising Pancreatitis. Gut, 68, 1044-1051. https://doi.org/10.1136/gutjnl-2017-314657 |
| [4] | Sarr, M.G., Banks, P.A., Bollen, T.L., Dervenis, C., Gooszen, H.G., Johnson, C.D., et al. (2013) The New Revised Classification of Acute Pancreatitis 2012. Surgical Clinics of North America, 93, 549-562. https://doi.org/10.1016/j.suc.2013.02.012 |
| [5] | Force, A.D.T., Ranieri, V.M., Rubenfeld, G.D., et al. (2012) Acute Respiratory Distress Syndrome: The Berlin Definition. JAMA, 307, 2526-2533. |
| [6] | Gorman, E.A., O’Kane, C.M. and McAuley, D.F. (2022) Acute Respiratory Distress Syndrome in Adults: Diagnosis, Outcomes, Long-Term Sequelae, and Management. The Lancet, 400, 1157-1170. https://doi.org/10.1016/s0140-6736(22)01439-8 |
| [7] | Bellani, G., Laffey, J.G., Pham, T., Fan, E., Brochard, L., Esteban, A., et al. (2016) Epidemiology, Patterns of Care, and Mortality for Patients with Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA, 315, 788-800. https://doi.org/10.1001/jama.2016.0291 |
| [8] | Laffey, J.G., Misak, C. and Kavanagh, B.P. (2017) Acute Respiratory Distress Syndrome. BMJ, 359, j5055. https://doi.org/10.1136/bmj.j5055 |
| [9] | 王映珍, 蒙雁飞, 马莉, 等. 胰腺炎相关急性呼吸窘迫综合征发病机制的研究进展[J]. 中国急救医学, 2021, 41(12): 1086-1090. |
| [10] | Browne, G.W. (2006) Pathophysiology of Pulmonary Complications of Acute Pancreatitis. World Journal of Gastroenterology, 12, 7087-7896. https://doi.org/10.3748/wjg.v12.i44.7087 |
| [11] | Wypych, T.P., Wickramasinghe, L.C. and Marsland, B.J. (2019) The Influence of the Microbiome on Respiratory Health. Nature Immunology, 20, 1279-1290. https://doi.org/10.1038/s41590-019-0451-9 |
| [12] | 阿依江·加马力丁, 王军红, 马青变. 重症急性胰腺炎肠道菌群变化的研究进展[J]. 中国急救医学, 2021, 41(5): 454-457. |
| [13] | Zhang, C., Liu, H., Wang, H., Tao, Q., Lin, X., Ge, S., et al. (2019) The Predictive Value of Potential Hematological Biomarkers in Acute Coronary Syndrome. Clinical Laboratory, 65. https://doi.org/10.7754/clin.lab.2019.181232 |
| [14] | Gomatos, I.P., Xiaodong, X., Ghaneh, P., Halloran, C., Raraty, M., Lane, B., et al. (2014) Prognostic Markers in Acute Pancreatitis. Expert Review of Molecular Diagnostics, 14, 333-346. https://doi.org/10.1586/14737159.2014.897608 |
| [15] | Wiese, M.L., Urban, S., von Rheinbaben, S., Frost, F., Sendler, M., Weiss, F.U., et al. (2022) Identification of Early Predictors for Infected Necrosis in Acute Pancreatitis. BMC Gastroenterology, 22, Article No. 405. https://doi.org/10.1186/s12876-022-02490-9 |
| [16] | 李思思, 何强, 徐有青. 全身炎症反应指数对急性胰腺炎患者严重程度的评估价值研究[J]. 中国全科医学, 2024, 27(17): 2104-2108. |
| [17] | Chen, X., Lin, Z., Chen, Y. and Lin, C. (2024) C-reactive Protein/lymphocyte Ratio as a Prognostic Biomarker in Acute Pancreatitis: A Cross-Sectional Study Assessing Disease Severity. International Journal of Surgery, 110, 3223-3229. https://doi.org/10.1097/js9.0000000000001273 |
| [18] | Pieri, G., Agarwal, B. and Burroughs, A.K. (2014) C-Reactive Protein and Bacterial Infection in Cirrhosis. Annals of Gastroenterology, 27, 113-120. |
| [19] | Kylänpää-Bäck, M., Takala, A., Kemppainen, E., Puolakkainen, P., Haapiainen, R. and Repo, H. (2001) Procalcitonin Strip Test in the Early Detection of Severe Acute Pancreatitis. Journal of British Surgery, 88, 222-227. https://doi.org/10.1046/j.1365-2168.2001.01673.x |
| [20] | Modrau, I.S., Floyd, A.K. and Thorlacius-Ussing, O. (2005) The Clinical Value of Procalcitonin in Early Assessment of Acute Pancreatitis. The American Journal of Gastroenterology, 100, 1593-1597. https://doi.org/10.1111/j.1572-0241.2005.41456.x |
| [21] | Cho, I.R., Do, M.Y., Han, S.Y., Jang, S.I. and Cho, J.H. (2023) Comparison of Interleukin-6, C-Reactive Protein, Procalcitonin, and the Computed Tomography Severity Index for Early Prediction of Severity of Acute Pancreatitis. Gut and Liver, 17, 629-637. https://doi.org/10.5009/gnl220356 |
| [22] | Tarján, D., Szalai, E., Lipp, M., Verbói, M., Kói, T., Erőss, B., et al. (2024) Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-analysis. International Journal of Molecular Sciences, 25, Article 1273. https://doi.org/10.3390/ijms25021273 |
| [23] | Wu, B.U., Hwang, J.Q., Gardner, T.H., Repas, K., Delee, R., Yu, S., et al. (2011) Lactated Ringer’s Solution Reduces Systemic Inflammation Compared with Saline in Patients with Acute Pancreatitis. Clinical Gastroenterology and Hepatology, 9, 710-717.e1. https://doi.org/10.1016/j.cgh.2011.04.026 |
| [24] | 覃月秋. 重症急性胰腺炎脓毒症发病机制的研究进展[J]. 医学综述, 2013, 19(8): 1359-1362. |
| [25] | 吕魁, 孙俊峰, 杨健鹰. 血清C反应蛋白、降钙素原、D-二聚体在急性胰腺炎患者中的表达及与严重程度床边指数和肺损伤的相关性[J]. 陕西医学杂志, 2023, 52(10): 1375-1378. |
| [26] | Zhang, G., Wang, G., Li, L., Hu, J., Ji, L., Li, Y., et al. (2019) Plasma D-Dimer Level Is an Early Predictor of Severity of Acute Pancreatitis Based on 2012 Atlanta Classification. Medical Science Monitor, 25, 9019-9027. https://doi.org/10.12659/msm.918311 |
| [27] | Wan, J., Yang, X., He, W., Zhu, Y., Zhu, Y., Zeng, H., et al. (2019) Serum D-Dimer Levels at Admission for Prediction of Outcomes in Acute Pancreatitis. BMC Gastroenterology, 19, Article No. 67. https://doi.org/10.1186/s12876-019-0989-x |
| [28] | 王方方, 田永红, 李影, 等. 急诊血流感染相关脓毒症休克患者入院时血钾、乳酸、RDW/PLT对病情和预后的预测价值 [J]. 中华医院感染学杂志, 2024, 34(24): 3711-3715. |
| [29] | 王桥生, 王美求, 符晖. 脓毒症相关急性呼吸窘迫综合征短期死亡风险评分标准构建[J]. 中国呼吸与危重监护杂志, 2022, 21(3): 162-169. |
| [30] | Shu, W., Wan, J., Chen, J., He, W., Zhu, Y., Zeng, H., et al. (2020) Initially Elevated Arterial Lactate as an Independent Predictor of Poor Outcomes in Severe Acute Pancreatitis. BMC Gastroenterology, 20, Article No. 116. https://doi.org/10.1186/s12876-020-01268-1 |
| [31] | Lu, F., Zhang, Y., Yu, J., Ge, Z. and Gu, L. (2023) Clinical Value of BISAP Score Combined with CRP and NLR in Evaluating the Severity of Acute Pancreatitis. Medicine, 102, e35934. https://doi.org/10.1097/md.0000000000035934 |
| [32] | Suppiah, A., Malde, D., Arab, T., Hamed, M., Allgar, V., Smith, A.M., et al. (2013) The Prognostic Value of the Neutrophil-Lymphocyte Ratio (NLR) in Acute Pancreatitis: Identification of an Optimal NLR. Journal of Gastrointestinal Surgery, 17, 675-681. https://doi.org/10.1007/s11605-012-2121-1 |
| [33] | Cao, W., Yao, X., Cen, D., Zhi, Y., Zhu, N. and Xu, L. (2020) The Prognostic Role of Platelet-to-Lymphocyte Ratio on Overall Survival in Gastric Cancer: A Systematic Review and Meta-Analysis. BMC Gastroenterology, 20, Article No. 16. https://doi.org/10.1186/s12876-020-1167-x |
| [34] | Hassanloo, J., Béland-Bonenfant, S., Paquette, M., Baass, A. and Bernard, S. (2022) Prevalence, Severity and Management of Hypertriglyceridemia-Associated Pancreatitis; a 7-Year Retrospective Cohort Study at Canadian Quaternary Care Hospitals. Journal of Clinical Lipidology, 16, 455-462. https://doi.org/10.1016/j.jacl.2022.05.064 |
| [35] | Lai, Q., Melandro, F., Laureiro, Z.L., Giovanardi, F., Corradini, S.G., Ferri, F., et al. (2018) Platelet-to-Lymphocyte Ratio in the Setting of Liver Transplantation for Hepatocellular Cancer: A Systematic Review and Meta-Analysis. World Journal of Gastroenterology, 24, 1658-1665. https://doi.org/10.3748/wjg.v24.i15.1658 |
| [36] | Zheng, F., Pan, Y., Yang, Y., Zeng, C., Fang, X., Shu, Q., et al. (2022) Novel Biomarkers for Acute Respiratory Distress Syndrome: Genetics, Epigenetics and Transcriptomics. Biomarkers in Medicine, 16, 217-231. https://doi.org/10.2217/bmm-2021-0749 |
| [37] | Bime, C., Casanova, N.G., Camp, S.M., Oita, R.C., Ndukum, J., Hernon, V.R., et al. (2022) Circulating eNAMPT as a Biomarker in the Critically Ill: Acute Pancreatitis, Sepsis, Trauma, and Acute Respiratory Distress Syndrome. BMC Anesthesiology, 22, Article No. 182. https://doi.org/10.1186/s12871-022-01718-1 |
| [38] | Yakah, W., Shah, I., Skelton-Badlani, D., Freedman, S.D., Popov, Y.V., Sheth, S.G., et al. (2023) Circulating Mitochondrial DNA as a Diagnostic Biomarker for Predicting Disease Severity in Patients with Acute Pancreatitis. Gastroenterology, 164, 1009-1011.e3. https://doi.org/10.1053/j.gastro.2023.01.013 |
| [39] | 何亚丽, 刘宏. 生长抑制特异性转录本5和微小RNA-142-3p在重症急性胰腺炎并急性呼吸窘迫综合征病人血清中的表达及临床意义[J]. 安徽医药, 2021, 25(5): 975-979. |
| [40] | 王培柱, 张毕明. 血清IL-6、IL-8、IL-10、IL-22水平与急性胰腺炎严重程度的相关性研究[J]. 国际医药卫生导报, 2021, 27(9): 1365-1369. |
| [41] | 毛恩强, 汤耀卿, 张圣道, 等. 重症胰腺炎感染期TNFα的变化及对器官功能的影响[J]. 中华肝胆外科杂志, 2002, 8(2): 97-99. |
| [42] | 齐颖, 陈兵. 血清IL-6联合Wnt5a及syndecan-1对急性胰腺炎患者合并急性呼吸窘迫综合征的预测价值[J]. 天津医科大学学报, 2022, 28(5): 541-544. |
| [43] | Dutta, A.K., Goel, A., Kirubakaran, R., Chacko, A. and Tharyan, P. (2020) Nasogastric versus Nasojejunal Tube Feeding for Severe Acute Pancreatitis. Cochrane Database of Systematic Reviews, 3, CD010582. https://doi.org/10.1002/14651858.cd010582.pub2 |
| [44] | Hirota, M. and Shimosegawa, T. (2020) [Continuous Regional Arterial Infusion of the Protease Inhibitor for Severe Acute Pancreatitis]. Nihon Shokakibyo Gakkai Zasshi, 117, 494-503. |
| [45] | Thompson, J.S., Schneider, P., Kalled, S.L., Wang, L., Lefevre, E.A., Cachero, T.G., et al. (2000) Baff Binds to the Tumor Necrosis Factor Receptor-Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population. The Journal of Experimental Medicine, 192, 129-136. https://doi.org/10.1084/jem.192.1.129 |
| [46] | Yang, H., Cao, R., Zhou, F., Wang, B., Xu, Q., Li, R., et al. (2024) The Role of Interleukin-22 in Severe Acute Pancreatitis. Molecular Medicine, 30, Article No. 60. https://doi.org/10.1186/s10020-024-00826-7 |
| [47] | 李蓉洁, 彭依, 唐小龙, 等. 改良BISAP评分系统的建立及其在重症急性胰腺炎早期诊断和预后评估中的意义[J]. 临床肝胆病杂志, 2023, 39(10): 2432-2442. |
| [48] | Jin, M., Bai, X., Chen, X., Zhang, H., Lu, B., Li, Y., et al. (2019) A 16-Year Trend of Etiology in Acute Pancreatitis: The Increasing Proportion of Hypertriglyceridemia-Associated Acute Pancreatitis and Its Adverse Effect on Prognosis. Journal of Clinical Lipidology, 13, 947-953.e1. https://doi.org/10.1016/j.jacl.2019.09.005 |
| [49] | 吴薇, 肖影, 王健, 等. CRP/Alb、NLR、PLR联合检测对重症急性胰腺炎合并ARDS的预测价值[J]. 疑难病杂志, 2023, 22(9): 951-955. |
