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病毒感染后葡萄膜炎一例
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Abstract:
目的：本文旨在分析病毒感染后引起的葡萄膜炎患者的临床特点及治疗方案。方法：收治1例经房水病原微生物宏基因组检测出病毒的葡萄膜炎患者，结合该患者情况及相关文献进行讨论与治疗。结果：患者经人免疫球蛋白及静脉激素冲击治疗后葡萄膜炎的症状迅速缓解，病情好转后出院。随访2个月，病情稳定，视力恢复良好。结论：葡萄膜炎是眼科常见的致盲性眼病，病毒感染是其重要原因。对于其引起的葡萄膜炎病人要做到早期明确诊断、个性化治疗以提升患者视力，改善疾病预后。
Objective: This paper aims to analyze the clinical characteristics and treatment plans of patients with uveitis caused by viral infection. Methods: One patient with uveitis, in whom viruses were detected by metagenomic testing of the aqueous humor for pathogenic microorganisms, was admitted and treated. The patient’s condition was discussed in combination with relevant literature. Results: After treatment with human immunoglobulin and intravenous corticosteroid pulse therapy, the symptoms of uveitis in the patient rapidly relieved, and the patient was discharged after the condition improved. After 2 months of follow-up, the condition was stable, and the visual acuity recovered well. Conclusion: Uveitis is a common blinding eye disease in ophthalmology, and viral infection is an important cause of it. For patients with uveitis caused by viral infection, early and definite diagnosis and personalized treatment should be carried out to improve the visual function of patients and the prognosis of the disease.
| [1] | Burton, M.J., Ramke, J., Marques, A.P., Bourne, R.R.A., Congdon, N., Jones, I., et al. (2021) The Lancet Global Health Commission on Global Eye Health: Vision Beyond 2020. The Lancet Global Health, 9, e489-e551. https://doi.org/10.1016/s2214-109x(20)30488-5 |
| [2] | World Health Organization (2019) World Report on Vision. https://www.who.int/publications/i/item/9789241516570 |
| [3] | Testi, I., Aggarwal, K., Jaiswal, N., Dahiya, N., Thng, Z.X., Agarwal, A., et al. (2021) Antiviral Therapy for Varicella Zoster Virus (VZV) and Herpes Simplex Virus (HSV)-Induced Anterior Uveitis: A Systematic Review and Meta-Analysis. Frontiers in Medicine, 8, Article 686427. https://doi.org/10.3389/fmed.2021.686427 |
| [4] | World Health Organization (2021) A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus, 6 October 2021. https://iris.who.int/handle/10665/345824 |
| [5] | Seah, I. and Agrawal, R. (2020) Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Ocular Immunology and Inflammation, 28, 391-395. https://doi.org/10.1080/09273948.2020.1738501 |
| [6] | Ho, D., Low, R., Tong, L., Gupta, V., Veeraraghavan, A. and Agrawal, R. (2020) COVID-19 and the Ocular Surface: A Review of Transmission and Manifestations. Ocular Immunology and Inflammation, 28, 726-734. https://doi.org/10.1080/09273948.2020.1772313 |
| [7] | Sanjay, S., Agrawal, S., Jayadev, C., Kawali, A., Gowda, P.B., Shetty, R., et al. (2021) Posterior Segment Manifestations and Imaging Features of Covid-19. Medical Hypothesis Discovery and Innovation in Ophthalmology, 10, 95-106. https://doi.org/10.51329/mehdiophthal1427 |
| [8] | Hsia, N., Hsu, A.Y., Wang, Y., Li, J., Chen, H., Wei, J.C., et al. (2023) The Risk Assessment of Uveitis after COVID‐19 Diagnosis: A Multicenter Population‐Based Study. Journal of Medical Virology, 95, e29188. https://doi.org/10.1002/jmv.29188 |
| [9] | Coperchini, F., Chiovato, L., Croce, L., Magri, F. and Rotondi, M. (2020) The Cytokine Storm in COVID-19: An Overview of the Involvement of the Chemokine/Chemokine-Receptor System. Cytokine & Growth Factor Reviews, 53, 25-32. https://doi.org/10.1016/j.cytogfr.2020.05.003 |
| [10] | Yang, D., Chu, H., Hou, Y., Chai, Y., Shuai, H., Lee, A.C., et al. (2020) Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated with Viral Antagonism of STAT1 Phosphorylation. The Journal of Infectious Diseases, 222, 734-745. https://doi.org/10.1093/infdis/jiaa356 |
| [11] | Sinha, A., Dwivedi, D., Dwivedi, A. and Bajaj, N. (2021) Optic Neuritis as a Presenting Symptom of Post-Covid-19 Multisystem Inflammatory Syndrome in Children (MIS-C). Indian Journal of Pediatrics, 88, 1269-1269. https://doi.org/10.1007/s12098-021-03921-3 |
| [12] | Chundru, K.J., Korte, J.E., Wen, C., Neelon, B., Wilson, D.A., Mateus, J., et al. (2024) Increasing Preterm Delivery and Small for Gestational Age Trends in South Carolina during the COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 21, Article 465. https://doi.org/10.3390/ijerph21040465 |
| [13] | Sanjay, S., Mutalik, D., Gowda, S., Mahendradas, P., Kawali, A. and Shetty, R. (2021) “Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis”. SN Comprehensive Clinical Medicine, 3, 1843-1847. https://doi.org/10.1007/s42399-021-00985-2 |
| [14] | 廖星星, 徐国兴. 葡萄膜炎的治疗进展[J]. 国际眼科杂志, 2020, 20(4): 631-634. |
| [15] | Ganesh, S.K. and Mohanan-Earatt, A. (2022) An Analysis of the Clinical Profile of Patients with Uveitis Following COVID-19 Infection. Indian Journal of Ophthalmology, 70, 1000-1006. https://doi.org/10.4103/ijo.ijo_2735_21 |
| [16] | Manni, P., Saturno, M.C. and Accorinti, M. (2023) Vogt-Koyanagi-Harada Disease and COVID. Journal of Clinical Medicine, 12, Article 6242. https://doi.org/10.3390/jcm12196242 |
| [17] | Ng, H.W., Scott, D.A.R., Danesh-Meyer, H.V., Smith, J.R., McGhee, C.N. and Niederer, R.L. (2024) Ocular Manifestations of Covid-19. Progress in Retinal and Eye Research, 102, Article ID: 101285. https://doi.org/10.1016/j.preteyeres.2024.101285 |
| [18] | Rishi, E., Thomas, J., Fashina, T., Kim, L. and Yeh, S. (2023) Emerging Pathogenic Viral Infections of the Eye. Annual Review of Vision Science, 9, 71-89. https://doi.org/10.1146/annurev-vision-100820-010504 |
