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HIFU治疗子宫腺肌症的分析：系统综述
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Abstract:
子宫腺肌症是育龄期女性常见的子宫良性疾病，对女性的身体健康造成极大的危害，HIFU (高强度聚焦超声)是一项通过体外超声聚焦于体内病变造成聚焦处凝固性坏死从而治疗疾病的一项术式，对改善子宫腺肌症患者的月经过多、进行性痛经，子宫增大、不孕等临床表现颇有成效，除此之外，在治疗过程中加用缩宫素、SonoVue (声诺维，一种造影剂)等有利于增加NPV (非灌注体积)，改善预后。HIFU联合GnRH-a或LNG-IUS等治疗亦有利于改善预后。HIFU手术最常见的不良反应是治疗区及下腹部疼痛、骶尾部疼痛、坐骨神经损伤引起的双下肢放射痛、阴道异常分泌物等，但是都在短期内可恢复，是一项安全、无创的治疗方式，可以解决不同部位、但位于声波通路的所有病变，具有优越的疗效，同时保持器官的完整性。
Adenomyosis is a common benign uterine disease in women of childbearing age, which poses great harm to women’s health. High-Intensity Focused Ultrasound (HIFU) is a therapeutic procedure that focuses extracorporeal ultrasound on intracorporeal lesions to induce coagulative necrosis at the focal point, thereby treating the disease. It has proven to be highly effective in improving clinical manifestations of adenomyosis, such as menorrhagia (heavy menstrual bleeding), progressive dysmenorrhea (painful menstruation), uterine enlargement, and infertility. In addition to HIFU treatment alone, the use of adjuncts such as oxytocin and SonoVue (a contrast agent) during the procedure helps to increase the Non-Perfused Volume (NPV) and improve the prognosis. HIFU combined with GnRH-a or LNG-IUS is also beneficial to improve prognosis. The most common adverse reactions of HIFU surgery are pain in the treatment area and lower abdomen, sacrococcygeal pain, radiation pain of both lower limbs caused by sciatic nerve injury, abnormal vaginal secretion, etc., but they can be recovered in a short time. It is a safe and non-invasive treatment method, which can solve all lesions in different parts but located in the acoustic pathway. It has superior curative effect and maintains the integrity of organs.
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