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免疫反应与IBD的发展
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Abstract:
炎症性肠病(Inflammatory Bowel Disease, IBD)是一种涉及肠道免疫失调、炎性细胞浸润、肠粘膜屏障破坏、肠腔内炎症细胞及细胞因子聚集等复杂病理过程的疾病。近年来在全球范围内发病率显著增加，并造成巨大的疾病负担。免疫反应包括先天性免疫应答及适应性免疫应答，在调节人类健康和疾病中起着至关重要的作用，同样，在IBD的发病过程中，其炎症细胞和细胞因子也发挥了极其重要的调控作用。本文对近年来IBD免疫反应及调控机制方面的研究进展进行综述，以期为IBD的研究及治疗提供新的思路和策略。
Inflammatory Bowel Disease (IBD) is a disease involving complex pathological processes such as intestinal immune disorders, inflammatory cell infiltration, intestinal mucosal barrier destruction, intestinal inflammatory cells and cytokine aggregation. In recent years, the incidence rate has increased significantly worldwide and caused a huge burden of disease. Immune response, including congenital immune response and adaptive immune response, plays a vital role in regulating human health and disease. Similarly, in the onset of IBD, its inflammatory cells and cytokines also play an extremely important regulatory role. This article reviews the research progress of IBD immune response and regulatory mechanism in recent years, with a view to providing new ideas and strategies for the research and treatment of IBD.
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