Introduction: Breast cancer is a global threat that mainly affects women. Worldwide, its prevalence in 2020 was 2.3 million cases and its incidence was 58.5 cases per 100,000 inhabitants. This study was conducted with the aim of describing the epidemiological and anatomo-pathological profile of breast cancer at Anoalite Hospital in Mungbere. Materials and Methods: This study was conducted at the Anoalite Hospital in Mungbere, located 138 km from Isiro, in the extreme northeast of the Haut-Uele province. This was a cross-sectional descriptive study with retrospective data collection, spanning from January 1, 2019 to December 31, 2023, i.e. over a period of 5 years. The study population consisted of any patient who visited the hospital during our study period. We used exhaustive sampling. Data collection was retrospective based on documentary technique. Data entry was carried out using Microsoft Office 365 Excel 2024 software and analyzed using Epi-Info CDC version 7.5.2.0 software. Results: The age group between 61 and 70 years was predominated (30%), single patients were the most affected (67.3%) and unemployed patients (66.8%). Most of the patients came from Isiro (27.6%). The paraclinical results showed that 82.0% had BI-RADS 5, while glucose tolerance abnormality was observed in 3.2% of patients. Infiltrating cancer was the most observed in our series (85.3%), among which 94.1% were carriers of the ductal type. On the other hand, among the 14.7% of patients who were carriers of in situ cancer, 53.1% had the ductal type. The majority of our respondents had grade III of SBR with 91.7%; 94.0% were estrogen receptor-positive and all patients had HER2 overexpressed status > 30%. Finally, all our subjects had Ki 67 ≥ 20%. Conclusion: Breast cancer is a real public health problem in our community. Several measures are needed to make early detection more accessible.
References
[1]
Anyigba, C.A., Awandare, G.A. and Paemka, L. (2021) Breast Cancer in Sub-Saharan Africa: The Current State and Uncertain Future. Experimental Biology and Medicine, 246, 1377-1387. https://doi.org/10.1177/15353702211006047
[2]
Fitzmaurice, C., Allen, C., Barber, R.M., Barregard, L., Bhutta, Z.A., Brenner, H., et al. (2017) Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 32 Cancer Groups, 1990 to 2015. JAMA Oncology, 3, 524-548. https://doi.org/10.1001/jamaoncol.2016.5688
[3]
Saucedo, M. and Deneux-Tharaux, C. (2024) Mortalité maternelle en France, 2016-2018, fréquence, causes et profil des femmes. Gynécologie Obstétrique Fertilité & Sénologie, 52, 185-200. https://doi.org/10.1016/j.gofs.2024.02.020
[4]
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. https://doi.org/10.3322/caac.21834
[5]
DeSantis, C.E., Fedewa, S.A., Goding Sauer, A., Kramer, J.L., Smith, R.A. and Jemal, A. (2015) Breast Cancer Statistics, 2015: Convergence of Incidence Rates between Black and White Women. CA: A Cancer Journal for Clinicians, 66, 31-42. https://doi.org/10.3322/caac.21320
[6]
Abdellatif, M. (2015) Epidemiological Data on Cancer in the World and in Morocco. Bibliographic Review. Annals of Health Sciences, 1, 20-29.
[7]
Raiah, M., Terki, K., Benrabah, L., Ammour, F., Lounis, A. and Ahmed Fouatih, Z. (2022) Épidémiologie des cancers en Algérie, 1996-2019. Bulletin du Cancer, 109, 909-915. https://doi.org/10.1016/j.bulcan.2022.05.003
[8]
Sulu, S.M.M., Mukuku, O., Sulu, A.M.S., Massamba, B.L., Mashinda, D.K. and Tshimpi, A.W. (2022) Knowledge regarding Breast Cancer among Congolese Women in Kinshasa, Democratic Republic of the Congo. Cancer Reports, 6, e1758. https://doi.org/10.1002/cnr2.1758
[9]
Mbala, K., Tozin, R., Mbala, N., Kamba, B., Sinamuli, K. and Omanga, U. (2019) Clinical and Molecular Profile of Breast Cancer in Kinshasa City Hospitals. Kismed—Artificial Intelligent Systems in Medicine, 9, 326-332.
[10]
Igiraneza, P.C., Omondi, L.A., Nikuze, B., Uwayezu, M.G., Fitch, M. and Niyonsenga, G. (2021) Cancer du sein chez les Rwandaises en âge de procréer du district sud de Kayonza: Facteurs influençant les pratiques de dépistage. Canadian Oncology Nursing Journal, 31, 258-265. https://doi.org/10.5737/23688076313258265
[11]
Hercules, S.M., Alnajar, M., Chen, C., Mladjenovic, S.M., Shipeolu, B.A., Perkovic, O., et al. (2022) Triple-Negative Breast Cancer Prevalence in Africa: A Systematic Review and Meta-Analysis. BMJ Open, 12, e055735. https://doi.org/10.1136/bmjopen-2021-055735
[12]
Motolouze, K., et al. (2023) Profil clinique, paraclinique et thérapeutique des patientes opérées du cancer du sein à l´Hôpital Gynéco-Obstétrique et Pédiatrique de Yaoundé (HGOPY). Pan African Medical Journal, 44, Article 2.
[13]
Kemfang Ngowa, J.D., Ebune, J.L., Ngassam, A., Atangana, J., Kabeyene, A. and Kasia, J.M. (2015) Clinicohistopathological Features and Molecular Markers of Breast Cancer in a Group of Patients at the Yaoundé General Hospital-Cameroon. African Journal of Cancer, 7, 108-112. https://doi.org/10.1007/s12558-015-0380-y
[14]
Elidrissi, E., Ouarzane, M., Boulouiz, R. and Bellaoui, M. (2016) Cancer Incidence in Eastern Morocco: Cancer Patterns and Incidence Trends, 2005-2012. BMC Cancer, 16, Article No. 356.
[15]
Ibrahim, N., Oludara, M., Ajani, A., Idowu, A., Adelusola, K., Popoola, A., et al. (2018) Socio-Demographic Factors and Reasons Associated with Delay in Breast Cancer Presentation: A Study in Nigerian Women. Breast, 39, 90-97.
[16]
Ly, M., Antoine, M., Dembélé, A.K. and Levy, P. (2019) Breast Cancer in Sub-Saharan Africa: Epidemiology, Management, and Challenges. Bulletin du Cancer, 106, 55-65.
[17]
Mphahlele, M., du Plessis, M. and van Wyk, C. (2019) Diagnostic Accuracy of Breast Ultrasound in South Africa: Correlation with BIRADS and Histopathology. South African Medical Journal, 109, 850-855.
[18]
Azim, H.A., Elghazawy, H., Ghazy, R.M., Abdelaziz, A.H., Abdelsalam, M., Elzorkany, A., et al. (2023) Clinicopathologic Features of Breast Cancer in Egypt—Contemporary Profile and Future Needs: A Systematic Review and Meta-Analysis. JCO Global Oncology, 9, e2200387. https://doi.org/10.1200/go.22.00387.
[19]
Dada, A. and Adekunle, A. (2020) Ultrasound Characteristics of Breast Cancer in Nigeria: Correlation with BI-RADS and Histopathological Findings. The Nigerian Journal of Radiology, 20, 25-30.
[20]
Okeke, G.C. and Onwudiwe, M. (2021) Glucose Metabolism and Its Association with Breast Cancer Outcomes in Nigerian Women. African Journal of Endocrinology and Metabolism, 7, 158-165.
[21]
Newman, L.A. (2017) Breast Cancer in Africa. Breast Cancer Research and Treatment, 165, 1-8.
[22]
Koffi, E., N’dri, Y. and Konaté, A. (2015) Clinicopathologic Features of Breast Cancer in Ivory Coast. Pan African Medical Journal, 22, Article 232.
[23]
Mbunda, N. and Mumba, D. (2018) Epidemiological Profile of Breast Cancer in Zambia: A Retrospective Study. Medical Journal of Zambia, 91, 95-101.
[24]
Diarra, S., Samake, M., Saye, A., Dembélé, B., Traoré, B., Dembélé, S.B., et al. (2023) Epidemiological, Diagnostic and Therapeutic Aspects of Breast Cancer in the Gynecology and Obstetrics Department of the CHU Gabriel Touré from 2020 to 2022. Advances in Breast Cancer Research, 12, 97-113. https://doi.org/10.4236/abcr.2023.123008
