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宫颈机能不全的病因学研究进展
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Abstract:
宫颈机能不全(cervical incompetence, CIC)是一种重要的产科疾病，其可导致复发性流产或早产，增加新生儿不良结局发生率。目前临床上还没有明确阐述CIC的发病机制，这与多种因素有关。结合以往研究报告的结果，对引起CIC高危因素的最新研究进展作一综述，为CIC的临床治疗和预防提供一定的参考依据。
Cervical insufficiency (CIC) is an important obstetric disease that can lead to recurrent miscarriage or preterm birth and increase the incidence of adverse neonatal outcomes. At present, the pathogenesis of CIC has not been clearly expounded in clinical practice, which is related to multiple factors. Based on the results of previous research reports, this paper reviews the latest research progress on the high-risk factors of CIC, providing certain reference basis for the clinical treatment and prevention of CIC.
| [1] | Debbs, R.H. and Chen, J. (2009) Contemporary Use of Cerclage in Pregnancy. Clinical Obstetrics & Gynecology, 52, 597-610. https://doi.org/10.1097/grf.0b013e3181beabaf |
| [2] | Sunderam, S., Kissin, D.M., Zhang, Y., Jewett, A., Boulet, S.L., Warner, L., et al. (2022) Assisted Reproductive Technology Surveillance—United States, 2018. MMWR. Surveillance Summaries, 71, 1-19. https://doi.org/10.15585/mmwr.ss7104a1 |
| [3] | Martin, J.A., Hamilton, B.E. and Osterman, M.J. (2012) Three Decades of Twin Births in the United States, 1980-2009. NCHS Data Brief, 80, 1-8. |
| [4] | Osterman, M., Hamilton, B., Martin, J.A., et al. (2021) Births: Final Data for 2020. National Vital Statistics Reports, 70, 1-50. |
| [5] | Slattery, M.M. and Morrison, J.J. (2002) Preterm Delivery. The Lancet, 360, 1489-1497. https://doi.org/10.1016/s0140-6736(02)11476-0 |
| [6] | Vogel, J.P., Chawanpaiboon, S., Moller, A., Watananirun, K., Bonet, M. and Lumbiganon, P. (2018) The Global Epidemiology of Preterm Birth. Best Practice & Research Clinical Obstetrics & Gynaecology, 52, 3-12. https://doi.org/10.1016/j.bpobgyn.2018.04.003 |
| [7] | 王永清, 赵扬玉. 宫颈机能不全的病因与诊断的研究进展[J]. 国际妇产科学杂志, 2016, 43(6): 630-633. |
| [8] | Maria, C., Mihaela, T., Mihaela, G., et al. (2012) Cervical Incompetence Associated with Congenital Uterine Malformations. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116, 1063-1068. |
| [9] | Panagiotopoulos, M., Tseke, P. and Michala, L. (2021) Obstetric Complications in Women with Congenital Uterine Anomalies According to the 2013 European Society of Human Reproduction and Embryology and the European Society for Gynaecological Endoscopy Classification: A Systematic Review and Meta-Analysis. Obstetrics & Gynecology, 139, 138-148. https://doi.org/10.1097/aog.0000000000004627 |
| [10] | Mastrolia, S.A., Baumfeld, Y., Hershkovitz, R., Loverro, G., Di Naro, E., Yohai, D., et al. (2016) Bicornuate Uterus Is an Independent Risk Factor for Cervical os Insufficiency: A Retrospective Population Based Cohort Study. The Journal of Maternal-Fetal & Neonatal Medicine, 30, 2705-2710. https://doi.org/10.1080/14767058.2016.1261396 |
| [11] | Lai, T.-. (2001) Successful Pregnancy by Transmyometrial and Transtubal Embryo Transfer after IVF in a Patient with Congenital Cervical Atresia Who Underwent Uterovaginal Canalization during Caesarean Section: Case Report. Human Reproduction, 16, 268-271. https://doi.org/10.1093/humrep/16.2.268 |
| [12] | Volozonoka, L., Rots, D., Kempa, I., Kornete, A., Rezeberga, D., Gailite, L., et al. (2020) Genetic Landscape of Preterm Birth Due to Cervical Insufficiency: Comprehensive Gene Analysis and Patient Next-Generation Sequencing Data Interpretation. PLOS ONE, 15, e0230771. https://doi.org/10.1371/journal.pone.0230771 |
| [13] | Anum, E.A., Hill, L.D., Pandya, A. and Strauss III, J.F. (2009) Connective Tissue and Related Disorders and Preterm Birth: Clues to Genes Contributing to Prematurity. Placenta, 30, 207-215. https://doi.org/10.1016/j.placenta.2008.12.007 |
| [14] | Raffi, F. and Anumba, D. (2007) Cervical Weakness Causing Recurrent Premature Births: Could This Be Familial? Journal of Obstetrics and Gynaecology, 27, 430-431. https://doi.org/10.1080/01443610701327271 |
| [15] | Gökçe, A., Şükür, Y.E., Özmen, B., Sönmezer, M., Berker, B., Aytaç, R., et al. (2020) The Association between Operative Hysteroscopy Prior to Assisted Reproductive Technology and Cervical Insufficiency in Second Trimester. Archives of Gynecology and Obstetrics, 303, 1347-1352. https://doi.org/10.1007/s00404-020-05863-1 |
| [16] | 韩晓欣, 王玉贤, 冯晶瑾. 双胎妊娠宫颈机能不全的不同处理对妊娠结局的影响[J]. 影像研究与医学应用, 2017, 1(1): 211-213. |
| [17] | Dickey, R.P., Olar, T.T., Taylor, S.N., Curole, D.N. and Matulich, E.M. (1993) Relationship of Endometrial Thickness and Pattern to Fecundity in Ovulation Induction Cycles: Effect of Clomiphene Citrate Alone and with Human Menopausal Gonadotropin. Fertility and Sterility, 59, 756-760. https://doi.org/10.1016/s0015-0282(16)55855-5 |
| [18] | 王伟, 姚书忠. 妊娠期宫颈机能不全诊治[J]. 实用妇产科杂志, 2018, 34(2): 90-93. |
| [19] | Feigenbaum, S.L., Crites, Y., Hararah, M.K., Yamamoto, M.P., Yang, J. and Lo, J.C. (2012) Prevalence of Cervical Insufficiency in Polycystic Ovarian Syndrome. Human Reproduction, 27, 2837-2842. https://doi.org/10.1093/humrep/des193 |
| [20] | Wu, Y., Cai, M., Liang, X. and Yang, X. (2020) The Prevalence of Cervical Insufficiency in Chinese Women with Polycystic Ovary Syndrome Undergone ART Treatment Accompanied with Negative Prognosis: A Retrospective Study. Journal of Obstetrics and Gynaecology, 41, 888-892. https://doi.org/10.1080/01443615.2020.1819212 |
| [21] | Gedikbasi, A., Yücel, B., Arslan, O., Giris, M., Gedikbasi, A. and Abbasoglu, S.D. (2015) Dynamic Collagen Changes in Cervix during the First Trimester and Decreased Collagen Content in Cervical Insufficiency. The Journal of Maternal-Fetal & Neonatal Medicine, 29, 2968-2972. https://doi.org/10.3109/14767058.2015.1109623 |
| [22] | 王磊, 任敏, 洪向丽, 等. 宫颈机能不全合并胰岛素抵抗对妊娠结局的影响[J]. 中华生殖与避孕杂志, 2020, 40(3): 225-229. |
| [23] | 李君. 子宫参数与PCOS患者的临床指标及早期妊娠的相关性分析[D]: [硕士学位论文]. 合肥: 安徽医科大学, 2019. |
| [24] | Perkhulyn, O.M., Pakharenko, L.V., Sukhin, V.S., Saltovskiy, O.V., Kovalchuk, V.M., Hranovska, H.I., et al. (2021) Evaluation of Hormonal Function in Women with Cervical Insufficiency and Infertility in the History. Wiadomości Lekarskie, 74, 2412-2416. https://doi.org/10.36740/wlek202110109 |
| [25] | Li, F., Yao, L., Wu, H., et al. (2016) Analysis on Endocrine and Metabolic Features of Different Phenotypes of Polycystic Ovary Syndrome Patients. Pakistan Journal of Pharmaceutical Sciences, 29, 1735-1738. |
| [26] | Son, G., Choi, S.Y., Ju, Y., Lee, K., Lee, J.J., Song, J., et al. (2021) Whole Blood RNA Sequencing Reveals a Differential Transcriptomic Profile Associated with Cervical Insufficiency: A Pilot Study. Reproductive Biology and Endocrinology, 19, Article No. 32. https://doi.org/10.1186/s12958-021-00715-2 |
| [27] | Musilova, I., Kolackova, M., Andrys, C., Drahosova, M., Baranová, I., Chmelarova, M., et al. (2019) Nicotinamide Phosphoribosyltransferase and Intra-Amniotic Inflammation in Preterm Prelabor Rupture of Membranes. The Journal of Maternal-Fetal & Neonatal Medicine, 34, 736-746. https://doi.org/10.1080/14767058.2019.1615049 |
| [28] | Monsanto, S.P., Daher, S., Ono, E., Pendeloski, K.P.T., Trainá, É., Mattar, R., et al. (2017) Cervical Cerclage Placement Decreases Local Levels of Proinflammatory Cytokines in Patients with Cervical Insufficiency. American Journal of Obstetrics and Gynecology, 217, 455.e1-455.e8. https://doi.org/10.1016/j.ajog.2017.06.024 |
| [29] | 顾珣可, 王丁然, 陶立元, 等. 宫颈机能不全孕妇血清松弛素水平的测定[J]. 中华医学杂志, 2015, 95(35): 2817-2820. |
| [30] | Venkatesh, K., Cantonwine, D., Zera, C., Arjona, M., Smith, N., Robinson, J., et al. (2016) Is There an Association between Body Mass Index and Cervical Length? Implications for Obesity and Cervical Length Management in Pregnancy. American Journal of Perinatology, 34, 568-575. https://doi.org/10.1055/s-0036-1594242 |
| [31] | Meng, L., Öberg, S., Sandström, A., Wang, C. and Reilly, M. (2022) Identification of Risk Factors for Incident Cervical Insufficiency in Nulliparous and Parous Women: A Population-Based Case-Control Study. BMC Medicine, 20, Article No. 348. https://doi.org/10.1186/s12916-022-02542-7 |
