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基于肠道菌群探讨2型糖尿病及中医药干预研究进展
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Abstract:
2型糖尿病(type 2 diabetes mellitus, T2DM)是全球面临的重要公共卫生挑战，近年来的研究表明肠道菌群在T2DM发病机制中扮演重要角色。中医药作为一种传统疗法，在调节肠道菌群方面展现出潜力。本文旨在探讨肠道菌群对T2DM的影响及中医药干预的最新研究进展。系统检索了相关文献，筛选出涉及肠道菌群与T2DM关系及中医药干预的研究，重点分析了关键菌种(如Blautia)和中医药的作用机制。现有研究表明，肠道菌群失调可能导致胰岛素抵抗和慢性炎症。而中医药通过调节肠道菌群和改善代谢状态，为糖尿病管理提供了新的策略。肠道菌群的调节为T2DM的治疗提供了新靶点，而中医药的有效干预将为T2DM治疗的综合管理提供新的视角。未来的研究应更深入探讨中医药的作用机制和临床应用。
Type 2 diabetes mellitus (T2DM) is a significant public health challenge worldwide. Recent studies have shown that the gut microbiota plays a crucial role in the pathogenesis of T2DM. Traditional Chinese medicine (TCM), as a conventional therapy, has demonstrated potential in regulating the gut microbiota. This article aims to explore the impact of the gut microbiota on T2DM and the latest research progress of TCM intervention. Relevant literature was systematically retrieved and studies involving the relationship between the gut microbiota and T2DM as well as TCM intervention were selected. Key bacterial species (such as Blautia) and the mechanism of action of TCM were analyzed in detail. Current research indicates that gut microbiota dysbiosis may lead to insulin resistance and chronic inflammation. TCM, by regulating the gut microbiota and improving metabolic status, provides a new strategy for diabetes management. The regulation of the gut microbiota offers new targets for the treatment of T2DM, and the effective intervention of TCM will provide a new perspective for the comprehensive management of T2DM treatment. Future research should further explore the mechanism of action and clinical application of TCM.
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