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手机使用时长与胃食管反流病风险：孟德尔随机化研究
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Abstract:
目的：通过孟德尔随机化(MR)方法探讨手机使用时长与胃食管反流的关联。方法：基于全基因组关联研究(GWAS)汇总数据，其中暴露(手机使用时长)数据456,972例，结局(胃食管反流病)数据602,604例。筛选出研究相关单核苷酸多态性(SNP)作为的工具变量，主要采用逆方差加权(IVW)法，加权中位数法、MR-Egger、简单模式和加权模式综合评估因果关系。Cochran Q检验用来评估异质性，MR-Egger截距法评估多效性，留一法进行敏感性分析。结果：26个显著相关的SNP纳入分析，IVW分析结果显示手机使用时长与胃食管反流病相关(OR = 1.600, 95%CI 1.301~1.967, P < 0.001)，SNP之间存在异质性(Q = 95.29, P < 0.001)，留一法分析显示单个SNP对整体结果无明显影响，MR-Egger截距法发现没有水平多效性(P > 0.05)。结论：手机使用时间过长与胃食管反流病相关，合理控制娱乐为目的的手机使用时长可能有助于减少胃食管反流病的发生。
Aims: To explore the association of length of mobile phone use and gastroesophageal reflux disease by Mendelian randomization (MR) method. Methods: Data were obtained from a genome-wide association study (GWAS) summary dataset, including 456,972 cases of exposure (length of mobile phone use) and outcomes of gastroesophageal reflux disease (602,604 cases). Single nucleotide polymorphisms (SNP) were selected as instrumental variables (IVs). Causal relationships were assessed using the inverse variance weighted (IVW), supplemented by the weighted median method, MR-Egger method, simple mode method, and weighted mode method. The Cochran Q test was employed to evaluate heterogeneity. Sensitivity analysis was performed using the leave-one-out method. The MR-Egger intercept method was used for pleiotropy testing. Results: 26 SNPs were included in the MR analysis. IVW indicated that the length of mobile phone use was associated with gastroesophageal reflux disease (OR = 1.600, 95%CI 1.301~1.967, P < 0.001). There was heterogeneity between SNPs (Q = 95.29, P < 0.001), leave-one-out analysis showed that a single SNP had no significant effect on the overall result, and MR-Egger intercept found no horizontal pleiotropy (P > 0.05). Conclusions: Length of mobile phone use is associated with gastroesophageal reflux disease. Reasonable control of mobile phone use time for recreational purposes may help to reduce the occurrence of gastroesophageal reflux disease.
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