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子宫内膜癌组织TFRC表达及其预后价值
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Abstract:
目的：探讨转铁蛋白受体(TFRC)在子宫内膜癌及癌旁组织中的表达、临床病理特征及预后价值。方法：以青岛市市立医院接受手术治疗的50例子宫内膜癌患者术后收集的子宫内膜癌组织及癌旁组织制备的石蜡切片为研究样本，利用免疫组化技术来评估转铁蛋白受体(TFRC)和Bcl-2在这两类组织中的表达特征，分析TFRC表达水平与子宫内膜癌患者预后之间的关联。结果：转铁蛋白受体(TFRC)在50例子宫内膜癌样本中的阳性表达率为68%，而在对应的癌旁组织中，该比率降至36%，两组之间的表达差异显示出显著的统计学意义(P < 0.01)，Bcl-2在50例子宫内膜癌组织样本中的阳性表达率为62%，而在对应的癌旁组织中，阳性表达率则为42%。两组之间的差异具有显著的统计学意义(P < 0.05)。TFRC和BCl-2在子宫内膜癌组织中的表达显著高于癌旁组织，且两者在癌组织中的表达呈正相关(r: 0.435, P < 0.01)。子宫内膜癌组织中，TFRC阳性表达与淋巴结转移和分期密切相关(P < 0.05)。并且TFRC阴性表达组5年生存率高于阳性表达组。BCl-2阳性表达与分化程度(P = 0.02)密切相关。结论：与癌旁组织相比，TFRC及Bcl-2这两种蛋白在子宫癌组织中的表达水平呈现出明显的升高趋势，且两者表达呈正相关，TFRC阳性表达与不良预后密切相关。
Objective: To investigate the expression, clinicopathological characteristics and prognostic value of transferrin receptor (TFRC) in endometrial cancer and paracancerous tissues. Methods: Paraffin sections of endometrial cancer tissues and paracancerous tissues collected from 50 endometrial cancer patients who underwent surgery in Qingdao Municipal Hospital were used as study samples, and immunohistochemistry was used to evaluate the expression characteristics of transferrin receptor (TFRC) and Bcl-2 in these tissues, and to analyze the correlation between the expression level of TFRC and the prognosis of patients with endometrial cancer. Results: The positive expression rate of transferrin receptor (TFRC) in 50 endometrial cancer tissue samples was 68%, while in the corresponding paracancerous tissues, the rate decreased to 36%, and the difference in expression between the two groups showed a statistically significant (P < 0.01), and the positive expression rate of Bcl-2 in 50 endometrial cancer tissue samples was 62%, while in the corresponding paracancerous tissues, the positive expression rate was 42%. The difference between the two groups was statistically significant (P < 0.05), and the expression of TFRC and BCl-2 in endometrial cancer tissues was significantly higher than that in paracarcinoma tissues, with a positive correlation between the two expressions in cancer tissues (r: 0.435, P < 0.01). In endometrial cancer tissues, TFRC positive expression was closely associated with lymph node metastasis and stage (P < 0.05). The 5-year survival rate was higher in the TFRC-negative group than in the TFRC-positive group, and the positive expression of BCl-2 was closely associated with the degree of differentiation (P = 0.02). Conclusions: Compared with paraneoplastic tissues, the expression levels of TFRC and Bcl-2 proteins in uterine
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