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幽门螺杆菌感染、炎症指标与早期结直肠癌的相关性分析
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Abstract:
目的：研究早期结直肠癌患者幽门螺杆菌感染情况及血液炎症指标的变化情况，探讨幽门螺杆菌感染、炎症指标与早期结直肠癌的相关性。方法：回顾性分析2020年9月至2023年9月就诊于青岛市市立医院的早期结直肠癌患者及同期住院的健康体检者，对两组研究对象的一般情况、幽门螺杆菌感染情况和血液炎症指标情况进行统计学比较分析，构建早期结直肠癌预测模型。结果：早期结直肠癌组幽门螺杆菌感染率和炎症指标水平均高于健康体检组，幽门螺杆菌感染和系统免疫炎症指数是影响早期结直肠癌发生的重要因素。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型的曲线下面积为0.803，预测概率的灵敏度和特异度分别为80.40%和67.90%。结论：幽门螺杆菌感染、炎症指标均与早期结直肠癌具有相关性，对早期结直肠癌的诊断具有积极意义。幽门螺杆菌和系统免疫炎症指数参与构建的早期结直肠癌预测模型对早期结直肠癌具有一定的诊断价值，对初步筛查早期结直肠癌高风险人群有一定的参考价值。
Objective: To study the changes in Helicobacter pylori infection and blood inflammatory indexes in patients with early colorectal cancer, and to explore the correlation between Helicobacter pylori infection, inflammatory indexes and early colorectal cancer. Methods: Early colorectal cancer patients attending Qingdao Municipal Hospital from September 2020 to September 2023 and health checkups hospitalized during the same period were retrospectively analyzed, and the general conditions, Helicobacter pylori infection and blood inflammation indexes of the two groups of study subjects were statistically compared and analyzed to construct a prediction model for early colorectal cancer. Results: The infection rate of Helicobacter pylori and the level of inflammatory indexes in the early colorectal cancer group were higher than those in the healthy medical checkup group, and Helicobacter pylori infection and systemic immune-inflammation indexes were important factors affecting the development of early colorectal cancer. The area under the curve of the early colorectal cancer prediction model constructed with the participation of Helicobacter pylori and the systemic immune-inflammation indexes was 0.803, and the sensitivity and specificity of the prediction probability were respectively 80.40% and 67.90%. Conclusion: Helicobacter pylori infection and inflammation indexes all correlate with early colorectal cancer, and have positive significance for the diagnosis of early colorectal cancer. The prediction model of early colorectal cancer constructed with the participation of Helicobacter pylori and systemic immune-inflammation indexes has a certain diagnostic value for early colorectal cancer, and has a certain reference value for the preliminary screening of high-risk groups of early colorectal cancer.
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