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踝肱指数与骨关节炎之间的关系：1999~2004年NHANES的数据
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Abstract:
目的：踝肱指数(ABI)与骨关节炎(OA)之间的关系仍不清楚。本研究旨在探讨ABI与OA患病率之间的潜在关联。方法：本研究共纳入了5172名来自美国国家健康与营养调查(1999~2004年)的ABI参与者。通过测量双臂(肱动脉)和双踝(胫后动脉)的收缩压来计算ABI。ABI分为三组：低(<0.90)、正常(0.90~1.40)和高(>1.40)。OA状态为自我报告。研究人员进行了加权多变量逻辑回归和亚组分析，以评估ABI与OA之间的独立关联。采用限制性立方体样条(RCS)方法探讨了剂量–反应关系。结果：经全面调整后的多变量逻辑回归分析结果显示，ABI越高，OA患病风险越高，两者之间存在显著关联。具体来说，ABI每增加一个单位，OA的发生几率就会增加3.01 [OR = 3.40; 95% CI: 1.38, 6.5; P = 0.01]。此外，剂量反应分析显示，ABI与OA患病率之间存在J型关联(非线性P为0.0769)，ABI超过1.1时，OA患病风险显著增加[OR = 1.31; 95% CI: 1.05, 1.63; P = 0.02]。结论：较高的ABI与OA风险增加有关。ABI可为OA的评估和治疗提供新的视角。
Objective: The relationship between ankle-brachial index (ABI) and osteoarthritis (OA) remains unclear. The aim of this study was to investigate the potential association between ABI and OA prevalence. Methods: A total of 5172 participants with ABI from the National Health and Nutrition Examination Survey (1999~2004) were included in this study. ABI was calculated by measuring systolic blood pressure in both arms (brachial artery) and both ankles (posterior tibial artery). ABI was classified into three groups: low (<0.90), normal (0.90~1.40), and high (>1.40). OA status was self-reported. The researchers performed weighted multivariate logistic regression and subgroup analyses to assess the independent association between ABI and OA. Dose-response relationships were explored using a restricted cubic spline (RCS) approach. Results: Fully adjusted multivariate logistic regression analyses showed a significant association between higher ABI and higher risk of OA prevalence. Specifically, each one-unit increase in ABI increased the odds of OA by 3.01 [OR = 3.40; 95% CI: 1.38, 6.5; P = 0.01]. In addition, dose-response analyses showed a J-shaped association between ABI and OA prevalence (non-linear P of 0.0769), with a significant increase in the risk of OA with an ABI above 1.1 [OR = 1.31; 95% CI: 1.05, 1.63; P = 0.02]. Conclusion: Higher ABI is associated with an increased risk of OA, and ABI may provide new perspectives for the assessment and treatment of OA.
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