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Sirtuins家族对结直肠癌的生物学功能及预后的研究进展
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Abstract:
Sirtuins蛋白家族具有ADP-核糖基转移酶活性和NAD+依赖性的组蛋白去乙酰基转移酶等多种酶活性，其家族包括Sirtuin1-7，是有名的长寿蛋白大家族，具有控制能量代谢、DNA修复、细胞活性、组织再生、炎症、神经元信号传递等多种生物学功能，同时在结直肠癌发生发展过程中作为不可替代的调控因素之一。Sirtuin1-7属于同一家族，但Sirtuin1-7表达对结肠癌的发生发展却有不同的影响，与患者预后也存在一定的相关性。本文综述了Sirtuins家族成员概述、在结直肠癌发生发展过程中所表达的生物学功能、作用机制及预后。
Sirtuins protein family has various enzyme activities such as ADP-ribosyl transferase activity and NAD+ dependent histone deacetyl transferase activity. Its family includes Sirtuin1-7, which is a well-known family of long-lived proteins. It has various biological functions such as controlling energy metabolism, DNA repair, cell activity, tissue regeneration, inflammation, neuronal signal transmission, etc., and serves as one of the irreplaceable regulatory factors in the occurrence and development of colorectal cancer. Sirtuin1-7 belongs to the same family, but the expression of Sirtuin1-7 has different effects on the occurrence and development of colon cancer, and has a certain correlation with the prognosis of patients. In this review, Sirtuins family members, biological functions, mechanisms of action and prognosis of colorectal cancer were summarized.
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