Skin diseases such as psoriasis, atopic dermatitis, burns, and other barrier insults pose ongoing therapeutic challenges, often requiring treatments that address both inflammation and skin barrier repair. The primary aim of this review is to provide a comprehensive overview of the potential benefits of sea buckthorn oil, derived from Hippophae rhamnoides, as a treatment for various skin diseases, detailing its anti-inflammatory properties, reporting benefits across several skin conditions, and highlighting challenges in formulation as well as preservation of the oil’s nutritional benefits. Drawing from a wide array of existing literature, this review investigates sea buckthorn oil’s rich composition of omega fatty acids, vitamins, and antioxidants, which may contribute to its therapeutic effects by modulating inflammatory pathways and enhancing skin barrier function. Clinical trials and patient case studies indicate that sea buckthorn oil shows promise in reducing erythema, inflammation, and improving skin sensitivity. However, challenges such as formulation stability, sourcing of quality oil, and variability in response to treatment across conditions need to be addressed. Future research should focus on optimizing formulations and conducting large-scale clinical trials to validate the therapeutic efficacy of sea buckthorn oil in the management of skin diseases. Additionally, further exploration of the regulatory mechanisms underlying its ability to modulate inflammation and repair the skin barrier is needed to fully elucidate its clinical potential. Sea buckthorn oil offers a novel and promising adjunctive treatment for psoriasis, atopic dermatitis, and wound-healing with significant potential to enhance therapeutic options for additional skin diseases.
References
[1]
Zielińska, A. and Nowak, I. (2017) Abundance of Active Ingredients in Sea-Buckthorn Oil. LipidsinHealthandDisease, 16, Article No. 95. https://doi.org/10.1186/s12944-017-0469-7
[2]
Solà Marsiñach, M. and Cuenca, A.P. (2019) The Impact of Sea Buckthorn Oil Fatty Acids on Human Health. LipidsinHealthandDisease, 18, Article No. 145. https://doi.org/10.1186/s12944-019-1065-9
[3]
Olas, B. (2018) The Beneficial Health Aspects of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) Oil. JournalofEthnopharmacology, 213, 183-190. https://doi.org/10.1016/j.jep.2017.11.022
[4]
Michalak, M., Pierzak, M., Kręcisz, B. and Suliga, E. (2021) Bioactive Compounds for Skin Health: A Review. Nutrients, 13, Article 203. https://doi.org/10.3390/nu13010203
[5]
Parke, M.A., Perez-Sanchez, A., Zamil, D.H. and Katta, R. (2021) Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function. DermatologyPractical&Conceptual, 11, e2021132. https://doi.org/10.5826/dpc.1101a132
[6]
Park, K. (2015) Role of Micronutrients in Skin Health and Function. Biomolecules&Therapeutics, 23, 207-217. https://doi.org/10.4062/biomolther.2015.003
[7]
Chen, Y., Cai, Y., Wang, K. and Wang, Y. (2023) Bioactive Compounds in Sea Buckthorn and Their Efficacy in Preventing and Treating Metabolic Syndrome. Foods, 12, Article 1985. https://doi.org/10.3390/foods12101985
[8]
Zhao, J., Liang, L., Zhang, W., Liu, X., Huo, G., Liu, X., et al. (2023) Sea Buckthorn Oil Regulates Primary Myoblasts Proliferation and Differentiation in Vitro. In VitroCellular&DevelopmentalBiology—Animal, 60, 139-150. https://doi.org/10.1007/s11626-023-00841-8
[9]
Yang, B. and Kallio, H.P. (2001) Fatty Acid Composition of Lipids in Sea Buckthorn (Hippophaërhamnoides L.) Berries of Different Origins. JournalofAgriculturalandFoodChemistry, 49, 1939-1947. https://doi.org/10.1021/jf001059s
[10]
Jaśniewska, A. and Diowksz, A. (2021) Wide Spectrum of Active Compounds in Sea Buckthorn (Hippophae rhamnoides) for Disease Prevention and Food Production. Antioxidants, 10, Article 1279. https://doi.org/10.3390/antiox10081279
[11]
Tudor, C., Bohn, T., Iddir, M., Dulf, F.V., Focşan, M., Rugină, D.O., et al. (2019) Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls. Nutrients, 12, Article 76. https://doi.org/10.3390/nu12010076
[12]
Dudau, M., Codrici, E., Tarcomnicu, I., Mihai, S., Popescu, I.D., Albulescu, L., et al. (2021) A Fatty Acid Fraction Purified from Sea Buckthorn Seed Oil Has Regenerative Properties on Normal Skin Cells. FrontiersinPharmacology, 12, Article 737571. https://doi.org/10.3389/fphar.2021.737571
[13]
Larmo, P.S., Yang, B., Hyssälä, J., Kallio, H.P. and Erkkola, R. (2014) Effects of Sea Buckthorn Oil Intake on Vaginal Atrophy in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Study. Maturitas, 79, 316-321. https://doi.org/10.1016/j.maturitas.2014.07.010
[14]
Chan, L., Yen, T., Tseng, Y., Yuen, T., Yuen, M., Yuen, H., et al. (2024) The Impact of Oral Sea-Buckthorn Oil on Skin, Blood Markers, Ocular, and Vaginal Health: A Randomized Control Trial. JournalofFunctionalFoods, 112, Article ID: 105973. https://doi.org/10.1016/j.jff.2023.105973
[15]
Wang, Z., Zhao, F., Wei, P., Chai, X., Hou, G. and Meng, Q. (2022) Phytochemistry, Health Benefits, and Food Applications of Sea Buckthorn (Hippophae rhamnoides L.): A Comprehensive Review. FrontiersinNutrition, 9, Article 1036295. https://doi.org/10.3389/fnut.2022.1036295
[16]
Balkrishna, A., Sakat, S.S., Joshi, K., Joshi, K., Sharma, V., Ranjan, R., et al. (2019) Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Sea Buckthorn (Hippophae rhamnoides) Oil. FrontiersinPharmacology, 10, Article 1186. https://doi.org/10.3389/fphar.2019.01186
[17]
Sulthana, S., Chary, P.S., Bhavana, V., Pardhi, E., Singh, S.B. and Mehra, N.K. (2023) Development and Evaluation Emulgel for Effective Management of the Imiquimod-Induced Psoriasis. Inflammopharmacology, 31, 301-320. https://doi.org/10.1007/s10787-022-01131-7
[18]
Boca, A., Ilies, R., Saccomanno, J., Pop, R., Vesa, S., Tataru, A., et al. (2018) Sea Buckthorn Extract in the Treatment of Psoriasis. ExperimentalandTherapeuticMedicine, 17, 1020-1023. https://doi.org/10.3892/etm.2018.6983
[19]
Yang, B. (1999) Effects of Dietary Supplementation with Sea Buckthorn (Hippophaë rhamnoides) Seed and Pulp Oils on Atopic Dermatitis. TheJournalofNutritionalBiochemistry, 10, 622-630. https://doi.org/10.1016/s0955-2863(99)00049-2
[20]
Hou, D., Di, Z., Qi, R., Wang, H., Zheng, S., Hong, Y., et al. (2017) Sea Buckthorn (Hippophaë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF-κB and STAT1 Activation. SkinPharmacologyandPhysiology, 30, 268-276. https://doi.org/10.1159/000479528
[21]
Wang, X., Li, S., Liu, J., Kong, D., Han, X., Lei, P., et al. (2020) Ameliorative Effects of Sea Buckthorn Oil on DNCB Induced Atopic Dermatitis Model Mice via Regulation the Balance of Th1/Th2. BMCComplementaryMedicineandTherapies, 20, Article No. 263. https://doi.org/10.1186/s12906-020-02997-2
[22]
Gu, Y., Wang, X., Liu, F., Zhang, J., Zhang, X., Liu, J., et al. (2022) Total Flavonoids of Sea Buckthorn (Hippophae rhamnoides L.) Improve Mc903-Induced Atopic Dermatitis-Like Lesions. JournalofEthnopharmacology, 292, Article ID: 115195. https://doi.org/10.1016/j.jep.2022.115195
[23]
World Health Organization (2018). Burns. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/burns
[24]
Sen, C.K., Gordillo, G.M., Roy, S., Kirsner, R., Lambert, L., Hunt, T.K., et al. (2009) Human Skin Wounds: A Major and Snowballing Threat to Public Health and the Economy. WoundRepairandRegeneration, 17, 763-771. https://doi.org/10.1111/j.1524-475x.2009.00543.x
[25]
Atiyeh, B.S., Gunn, S.W. and Hayek, S.N. (2005) State of the Art in Burn Treatment. WorldJournalofSurgery, 29, 131-148. https://doi.org/10.1007/s00268-004-1082-2
[26]
Herndon, D.N. (2012) Total Burn Care. 4th Edition, Saunders Elsevier.
[27]
Abdullahzadeh, M. and Shafiee, S. (2021) To Compare the Effect of sea Buckthorn and Silver Sulfadiazine Dressing on Period of Wound Healing in Patients with Second-Degree Burns: A Randomized Triple-Blind Clinical Trial. WoundRepairandRegeneration, 29, 732-740. https://doi.org/10.1111/wrr.12916
[28]
Ren, R., Li, N., Su, C., Wang, Y., Zhao, X., Yang, L., et al. (2020) The Bioactive Components as Well as the Nutritional and Health Effects of Sea Buckthorn. RSCAdvances, 10, 44654-44671. https://doi.org/10.1039/d0ra06488b
[29]
Koskovac, M., Cupara, S., Kipic, M., Barjaktarevic, A., Milovanovic, O., Kojicic, K., et al. (2017) Sea Buckthorn Oil—A Valuable Source for Cosmeceuticals. Cosmetics, 4, Article 40. https://doi.org/10.3390/cosmetics4040040
[30]
Zhang, H., Song, G., Ma, W., Guo, M., Ling, X., Yu, D., et al. (2023) Microencapsulation Protects the Biological Activity of Sea Buckthorn Seed Oil. FrontiersinNutrition, 9, Article 1043879. https://doi.org/10.3389/fnut.2022.1043879
[31]
Zhang, X., Li, M., Zhu, L., Geng, Z., Liu, X., Cheng, Z., et al. (2023) Sea Buckthorn Pretreatment, Drying, and Processing of High-Quality Products: Current Status and Trends. Foods, 12, Article 4255. https://doi.org/10.3390/foods12234255
[32]
Singh, M.N., Hemant, K.S., Ram, M. and Shivakumar, H.G. (2010) Microencapsulation: A Promising Technique for Controlled Drug Delivery. Research in Pharmaceutical Sciences, 5, 65-77.
[33]
Dinkar Gore, D., Ahmad, F., Tikoo, K., Kumar Bansal, A., Kumar, D. and Pal Singh, I. (2023) Comparative Quantitative Analysis of Fruit Oil from Hippophae rhamnoides (Seabuckthorn) by qNMR, FTIR and GC-MS. ChineseHerbalMedicines, 15, 607-613. https://doi.org/10.1016/j.chmed.2023.05.005
[34]
Zosimidou, S.S., Vouvoudi, E.C., Tsagkalias, I.S., Lykidou, S.S. and Nikolaidis, N.F. (2023) Preparation of Cosmetic Emulsions Containing Hippophae Oil Isolated by Various Methods: Study of Their Antioxidant, Sun-Blocking and Physicochemical Properties. Antioxidants, 12, Article 1829. https://doi.org/10.3390/antiox12101829
[35]
Beveridge, T., Li, T.S.C., Oomah, B.D. and Smith, A. (1999) Sea Buckthorn Products: Manufacture and Composition. JournalofAgriculturalandFoodChemistry, 47, 3480-3488. https://doi.org/10.1021/jf981331m
[36]
Manea, A.M., Ungureanu, C. and Meghea, A. (2014) Effect of Vegetable Oils on Obtaining Lipid Nanocarriers for Sea Buckthorn Extract Encapsulation. Comptes Rendus Chimie, 17, 934-943.
[37]
Lee, S., Gura, K.M., Kim, S., Arsenault, D.A., Bistrian, B.R. and Puder, M. (2006) Current Clinical Applications of ω-6 and ω-3 Fatty Acids. NutritioninClinicalPractice, 21, 323-341. https://doi.org/10.1177/0115426506021004323
[38]
Bal, L.M., Meda, V., Naik, S.N. and Satya, S. (2011) Sea Buckthorn Berries: A Potential Source of Valuable Nutrients for Nutraceuticals and Cosmeceuticals. Food Research International, 44, 1718-1727.
[39]
Kallio, H., Yang, B., Peippo, P., Tahvonen, R. and Pan, R. (2002) Triacylglycerols, Glycerophospholipids, Tocopherols, and Tocotrienols in Berries and Seeds of Two Subspecies (ssp. sinensis and mongolica) of Sea Buckthorn (Hippopha>ë rhamnoides). JournalofAgriculturalandFoodChemistry, 50, 3004-3009. https://doi.org/10.1021/jf011556o
[40]
Li, T.S.C. and Schroeder, W.R. (1996) Sea Buckthorn (Hippophae rhamnoides L.): A Multipurpose Plant. HortTechnology, 6, 370-380. https://doi.org/10.21273/horttech.6.4.370
