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肾性骨病的分子调控机制及中医药研究进展
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Abstract:
慢性肾脏病(CKD)是由多种肾脏疾病长期发展而来的慢性进展性疾病，肾性骨病(renal osteopathy)是慢性肾脏病晚期与血液透析患者的重要并发症。通常由肾小球滤过功能下降引起钙磷代谢紊乱和继发性甲状旁腺功能亢进，进而引发骨形成与吸收的异常，以骨骼畸形、骨质疏松、骨痛、软组织和血管钙化以及皮肤瘙痒等为主要表现。该文论述了肾性骨病的相关分子通路及治疗肾性骨病方面应用较为广泛的中药单体和复方的作用机制，旨在为中药防治肾性骨病的临床应用及新药研发提供思路。
Chronic kidney disease (CKD) is a progressive long-term condition that evolves from various renal disorders. Renal osteopathy, a significant complication in advanced CKD and hemodialysis patients, is typically caused by the decline in glomerular filtration rate, leading to calcium-phosphorus metabolism disorders and secondary hyperparathyroidism. This, in turn, triggers abnormalities in bone formation and resorption, characterized by skeletal deformities, osteoporosis, bone pain, soft tissue and vascular calcification, and skin itching. The article discusses the molecular pathways associated with renal osteopathy and the mechanisms of action of widely used monomers and compound formulations of traditional Chinese medicine in treating this condition. The aim is to provide insights for the clinical application and development of new drugs for the prevention and treatment of renal osteopathy using traditional Chinese medicine.
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