|
|
GLCCI1基因在儿童激素抵抗性哮喘的研究进展
|
Abstract:
支气管哮喘是中国儿童常见的慢性肺部疾病，对于哮喘急性期的药物治疗主要是全身应用糖皮质激素(GC)、哮喘缓解期的药物主要是吸入性糖皮质激素(ICS)，其中有一部分成人、儿童使用GC治疗后效果仍然不理想，这不利于哮喘儿童的治疗及预后。有越来越多的研究表明糖皮质激素诱导的转录本1 (GLCCI1)基因在哮喘发生及GC治疗中发挥重要作用。本文将在GLCCI1基因多态性在糖皮质激素抵抗性哮喘(SRA)的影响方面进行阐述。
Bronchial asthma is a common chronic lung disease in Chinese children. For acute stage of asthma, systemic glucocorticoid (GC) is the main drug treatment, and for asthma remission stage, inhaled glucocorticoid (ICS) is the main drug treatment. Some adults and children still have unsatisfactory effects after GC treatment, which is not conducive to the treatment and prognosis of children with asthma. More and more studies have shown that glucocorticoid-induced transcript 1 (GLCCI1) gene plays an important role in asthma development and GC treatment. This article will discuss the effect of GLCCI1 gene polymorphism on glucocorticoid-resistant asthma (SRA).
| [1] | Haktanir Abul, M. and Phipatanakul, W. (2019) Severe Asthma in Children: Evaluation and Management. Allergology International, 68, 150-157. https://doi.org/10.1016/j.alit.2018.11.007 |
| [2] | Asher, M.I., Rutter, C.E., Bissell, K., Chiang, C., El Sony, A., Ellwood, E., et al. (2021) Worldwide Trends in the Burden of Asthma Symptoms in School-Aged Children: Global Asthma Network Phase I Cross-Sectional Study. The Lancet, 398, 1569-1580. https://doi.org/10.1016/s0140-6736(21)01450-1 |
| [3] | 吴嘉婴, 洪建国. 儿童支气管哮喘诊断和防治指南(2016年版)更新要点[J]. 世界临床药物, 2018, 39(8): 512-517. |
| [4] | 吴迎爽, 薛向东, 王大伟, 等. 支气管哮喘患儿对糖皮质激素的反应性与PVT1的相关性研究[J]. 重庆医学, 2020, 49(24): 4143-4146. |
| [5] | 李锦秀, 包爱华. 激素抵抗性哮喘的发病机制及治疗研究进展[J]. 临床肺科杂志, 2023, 28(12): 1898-1902. |
| [6] | 张仕清, 张倩. 上皮间质转化与重度哮喘糖皮质激素抵抗的关系研究进展[J]. 大连医科大学学报, 2022, 44(2): 163-168. |
| [7] | 李亚如. GLCCI1通过STAT3调控内质网应激抑制糖尿病小鼠视网膜Müller细胞炎症[D]: [硕士学位论文]. 锦州: 锦州医科大学, 2023. |
| [8] | 李晶晶, 高文博, 田英娜, 等. GLCCI1基因多态性对糖皮质激素治疗下呼吸道感染临床疗效的影响[J]. 中华医院感染学杂志, 2022, 32(18): 2752-2756. |
| [9] | 杜甜甜, 付希安, 孙勇虎, 等. 中国汉族大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感无相关性[J]. 中国麻风皮肤病杂志, 2016, 32(12): 724-726. |
| [10] | 马业. 哮喘患儿CRHR1、GLCCI1不同基因分型对吸入糖皮质激素敏感性分析[D]: [硕士学位论文]. 乌鲁木齐: 新疆医科大学, 2019. |
| [11] | Kiuchi, Z., Nishibori, Y., Kutsuna, S., Kotani, M., Hada, I., Kimura, T., et al. (2019) GLCCI1 Is a Novel Protector against Glucocorticoid-Induced Apoptosis in T Cells. The FASEB Journal, 33, 7387-7402. https://doi.org/10.1096/fj.201800344rr |
| [12] | 王星翘, 尹琴, 王天祺, 等. 哮喘患者GLCCI1基因检测指导吸入糖皮质激素的安全性用药效果[J]. 实用临床医药杂志, 2017, 21(1): 34-36 |
| [13] | 周淑新. WONCA研究论文摘要汇编——GLCCI1与糖皮质激素哮喘疗法反应的基因组相关[J]. 中国全科医学, 2011, 14(36): 4227. |
| [14] | 任丹阳, 李云巍, 涂彩霞, 等. ADRB2、GLCCI1、FCER2基因检测在2例难治性哮喘患儿个体化用药中的实践[J]. 中国药房, 2018, 29(5): 659-662. |
| [15] | 邱玉明, 李剑雄, 李慧. GLCCI1基因rs37973位点多态性与哮喘的相关性[J]. 广东医学, 2017, 38(S1): 22-24. |
| [16] | Xun, Q., Kuang, J., Yang, Q., Wang, W. and Zhu, G. (2021) GLCCI1 Reduces Collagen Deposition and Airway Hyper-Responsiveness in a Mouse Asthma Model through Binding with WD Repeat Domain 45b. Journal of Cellular and Molecular Medicine, 25, 6573-6583. https://doi.org/10.1111/jcmm.16658 |
| [17] | Xia, F., Deng, C., Jiang, Y., Qu, Y., Deng, J., Cai, Z., et al. (2018) IL4 (Interleukin 4) Induces Autophagy in B Cells Leading to Exacerbated Asthma. Autophagy, 14, 450-464. https://doi.org/10.1080/15548627.2017.1421884 |
| [18] | 薛庆辉. miR-130a-3p通过靶向调节自噬相关蛋白7影响儿童支气管哮喘的Th1/Th2平衡和气道重塑[J]. 福建医科大学学报, 2023, 57(4): 252-257. |
| [19] | 陈芬. 急性支气管哮喘患儿血清白三烯B4、白介素17和肺功能的变化及临床意义[J]. 中西医结合心血管病电子杂志, 2020, 8(20): 174. |
| [20] | 蒋媛媛. GLCCI1负向调控M1巨噬细胞活化参与哮喘激素敏感性降低机制[D]: [博士学位论文]. 长沙: 中南大学, 2023. |
| [21] | Hu, C.P., Xun, Q.F., Li, X.Z., et al. (2018) Effects of Glucocorticoid-Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice. Chinese Medical Journal, 131, 2817-2826. |
| [22] | Hirai, K., Shirai, T., Rachi, Y., Uehara, S., Ueda, M., Nakatani, E., et al. (2019) Impact of Gene Expression Associated with Glucocorticoid-Induced Transcript 1 (GLCCI1) on Severe Asthma and Future Exacerbation. Biological and Pharmaceutical Bulletin, 42, 1746-1752. https://doi.org/10.1248/bpb.b19-00476 |
| [23] | Jiang, Y., Xun, Q., Wan, R., Deng, S., Hu, X., Luo, L., et al. (2021) GLCCI1 Gene Body Methylation in Peripheral Blood Is Associated with Asthma and Asthma Severity. Clinica Chimica Acta, 523, 97-105. https://doi.org/10.1016/j.cca.2021.09.006 |
| [24] | Voegel, J.J., Heine, M.J., Zechel, C., Chambon, P. and Gronemeyer, H. (1996) TIF2, a 160 Kda Transcriptional Mediator for the Ligand-Dependent Activation Function AF-2 of Nuclear Receptors. The EMBO Journal, 15, 3667-3675. https://doi.org/10.1002/j.1460-2075.1996.tb00736.x |
| [25] | Huang, J., Hu, X., Zheng, X., Kuang, J., Liu, C., Wang, X., et al. (2020) Effects of STIP1 and GLCCI1 Polymorphisms on the Risk of Childhood Asthma and Inhaled Corticosteroid Response in Chinese Asthmatic Children. BMC Pulmonary Medicine, 20, Article No. 303. https://doi.org/10.1186/s12890-020-01332-2 |
| [26] | Xun, Q., Hu, C., Li, X., Hu, X., Qin, L., He, R., et al. (2019) GLCCI1 rs37973 Is Associated with the Response of Adrenal Hormone to Inhaled Corticosteroids in Asthma. World Allergy Organization Journal, 12, Article ID: 100017. https://doi.org/10.1016/j.waojou.2019.100017 |
| [27] | Hu, X., Deng, S., Luo, L., Jiang, Y., Ge, H., Yin, F., et al. (2021) GLCCI1 Deficiency Induces Glucocorticoid Resistance via the Competitive Binding of IRF1: GRIP1 and IRF3: GRIP1 in Asthma. Frontiers in Medicine, 8, Article 686493. https://doi.org/10.3389/fmed.2021.686493 |
| [28] | 李晓辉, 李奕, 赵二要. GLCCI1基因rs37973位点多态性与支气管哮喘患儿糖皮质激素治疗效果及肺功能的关系[J]. 中国合理用药探索, 2021, 18(10): 51-55. |
| [29] | Feng, W., Pu, W., Li, J., Yuan, Y., Yan, M., Yuan, S., et al. (2023) The glcci1 rs37973 Variant and the Efficacy of Inhaled Corticosteroids in the Treatment of Asthma: A Meta-Analysis. The Clinical Respiratory Journal, 17, 568-579. https://doi.org/10.1111/crj.13627 |
