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血管性认知障碍血浆生物标志物的研究进展
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Abstract:
血管性认知障碍(VCI)主要由血管危险因素和脑血管疾病引起。VCI包括广泛的认知障碍，从轻度认知障碍到缺血性或出血性卒中引起的血管性痴呆，也包含合并阿尔茨海默病等混合性病理所致的不同程度的认知障碍。目前针对VCI的药物治疗研究多集中在VaD (重度VCI)，且这些效果并未带来日常生活能力的明显改善。寻找新的生物标志物是对VCI进行诊断和治疗的关键一步。近年来，以血液为标本筛选合适的VCI生物标志物研究得到了广泛开展。本文旨在对血浆中血管性认知障碍生物标志物的研究现状进行综述，以寻找适合VCI患者诊断的生物学工具。
Vascular cognitive impairment (VCI) is mainly caused by vascular risk factors and cerebrovascular disease. VCI includes a wide range of cognitive impairments, from mild cognitive impairment to vascular dementia due to ischemic or hemorrhagic stroke, as well as varying degrees of cognitive deficits due to comorbid pathologies such as Alzheimer’s disease. Current pharmacotherapy studies for VCI have focused on VaD (severe VCI), and these effects have not led to significant improvements in the ability to perform activities of daily living. The search for new biomarkers is a crucial step in the diagnosis and treatment of VCI. In recent years, blood-based specimen screening studies for suitable biomarkers of VCI have been widely conducted. The aim of this paper is to review the current status of research on biomarkers of vascular cognitive impairment in plasma in order to find suitable biological tools for the diagnosis of patients with VCI.
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