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促炎性脂肪因子与2型糖尿病肾病的研究进展
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Abstract:
脂肪因子(adipokines)是由脂肪组织分泌的细胞家族，广泛参与机体糖、脂代谢的调节及血管内皮功能。随着人们生活水平的提高，肥胖在全球范围流行，促进了代谢相关疾病的发生，尤其是糖尿病(DM)在世界范围内快速发展，目前在我国主要以2型糖尿病(T2DM)为主，成为一种多发病和常见病，2型糖尿病微血管并发症是其致死致残的主要原因。T2DM发病关键环节是外周组织的胰岛素抵抗和胰岛B细胞功能缺陷。胰岛素抵抗可能是其发病的根本原因，而肥胖尤其是内脏脂肪肥胖与胰岛素抵抗密切相关。
Adipokines, a family of cells secreted by adipose tissue, are widely involved in the regulation of glucose and lipid metabolism and vascular endothelial function. With the improvement of people’s living standards, obesity has become a global epidemic, which has promoted the occurrence of metabolic diseases, especially diabetes mellitus (DM) in the world, the rapid development of type 2 diabetes mellitus (T2DM) in China is mainly dominated by type 2 diabetes, which has become a kind of frequently-occurring and common disease, and microvascular complications of type 2 diabetes mellitus are the main cause of death and disability. The key links of T2DM pathogenesis are peripheral tissue insulin resistance and islet B cell dysfunction. Insulin resistance may be the root cause of its pathogenesis, and obesity, especially visceral fat obesity, is closely related to insulin resistance.
| [1] | Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G. and Catalán, V. (2018) Adipokine Dysregulation and Adipose Tissue Inflammation in Human Obesity. European Journal of Clinical Investigation, 48, e12997. https://doi.org/10.1111/eci.12997. |
| [2] | 李想, 董文婷, 霍金海, 等. 脂肪组织与代谢性疾病的研究进展[J]. 黑龙江中医药, 2021, 50(3): 454-455. |
| [3] | Kim, J., Kim, J., Jo, M., Cho, E., Ahn, S., Kwon, Y. and Ko, G. (2022) The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome. Molecules, 27, Article 334. https://doi.org/10.3390/molecules27020334 |
| [4] | Kirichenko, T.V., Markina, Y.V., Bogatyreva, A.I., Tolstik, T.V., Varaeva, Y.R. and Starodubova, A.V. (2022) The Role of Adipokines in Inflammatory Mechanisms of Obesity. International Journal of Molecular Sciences, 23, Article 14982. https://doi.org/10.3390/ijms232314982 |
| [5] | Reiterer, M., Gilani, A. and Lo, J.C. (20222) Pancreatic Islets as a Target of Adipokines. Comprehensive Physiology, 12, 4039-4065. https://doi.org/10.1002/cphy.c210044 |
| [6] | 张玉玲, 隆敏. 新型脂肪因子在肥胖和2型糖尿病中的研究进展[J]. 中国临床研究, 2023, 36(12): 1769-1775. https://doi.org/10.13429/j.cnki.cjcr.2023.12.001 |
| [7] | Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P.K., Del Solar, M., Zhu, B., York, B., Sarkar, P., Rendon, D.A., Gaber, M.W., LeMaire, S.A., Coselli, J.S., Milewicz, D.M., Sutton, V.R., Butte, N.F., Moore, D.D. and Chopra, A.R. (2016) Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell, 165, 566-579. https://doi.org/10.1016/j.cell.2016.02.063 |
| [8] | Goodarzi, G., Setayesh, L., Fadaei, R., Khamseh, M.E., Aliakbari, F., Hosseini, J. and Moradi, N. (2021) Circulating Levels of Asprosin and Its Association with Insulin Resistance and Renal Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy. Molecular Biology Reports, 48, 5443-5450. https://doi.org/10.1007/s11033-021-06551-2 |
| [9] | Wang, R., Lin, P., Sun, H. and Hu, W. (2021) Increased Serum Asprosin Is Correlated with Diabetic Nephropathy. Diabetology & Metabolic Syndrome, 13, Article No. 51. https://doi.org/10.1186/s13098-021-00668-x |
| [10] | Deng, X., Zhao, L., Guo, C., Yang, L., Wang, D., Li, Y., Xia, H., Wang, C., Cai, Z., Li, L., Zhao, Z. and Yuan, G. (2020) Higher Serum Asprosin Level Is Associated with Urinary Albumin Excretion and Renal Function in Type 2 Diabetes. Diabetes, Metabolic Syndrome and Obesity, 13, 4341-4351. https://doi.org/10.2147/dmso.s283413 |
| [11] | Goodarzi, G., Setayesh, L., Fadaei, R., Khamseh, M.E., Aliakbari, F., Hosseini, J. and Moradi, N. (2021) Circulating Levels of Asprosin and Its Association with Insulin Resistance and Renal Function in Patients with Type 2 Diabetes Mellitus and Diabetic Nephropathy. Molecular Biology Reports, 48, 5443-5450. https://doi.org/10.1007/s11033-021-06551-2 |
| [12] | Yuan, M., Li, W., Zhu, Y., Yu, B. and Wu, J. (2020) Asprosin: A Novel Player in Metabolic Diseases. Frontiers in Endocrinology, 11, Article 64. https://doi.org/10.3389/fendo.2020.00064 |
| [13] | Diao, H., Li, X., Xu, Y., Xing, X. and Pang, S. (2023) Asprosin, a Novel Glucogenic Adipokine Implicated in Type 2 Diabetes Mellitus. Journal of Diabetes and Its Complications, 37, Article ID: 108614. https://doi.org/10.1016/j.jdiacomp.2023.108614 |
| [14] | Farrag, M., Ait Eldjoudi, D., González-Rodríguez, M., Cordero-Barreal, A., Ruiz-Fernández, C., Capuozzo, M., González-Gay, M.A., Mera, A., Lago, F., Soffar, A., Essawy, A., Pino, J., Farrag, Y. and Gualillo, O. (2023) Asprosin in Health and Disease, a New Glucose Sensor with Central and Peripheral Metabolic Effects. Frontiers in Endocrinology, 13, Article 1101091. https://doi.org/10.3389/fendo.2022.1101091. |
| [15] | 甘甜. 2型糖尿病肾脏病变患者血浆asprosin水平的变化及意义[D]: [硕士学位论文]. 太原: 山西医科大学, 2023. https://doi.org/10.27288/d.cnki.gsxyu.2021.001185 |
| [16] | Kang, Y.S. and Cha, D.R. (2011) The Role of Visfatin in Diabetic Nephropathy. Chonnam Medical Journal, 47, 139-143. https://doi.org/10.4068/cmj.2011.47.3.139 |
| [17] | Liu, L., Shi, Z., Ji, X., Zhang, W., Luan, J., Zahr, T. and Qiang, L. (2022) Adipokines, Adiposity, and Atherosclerosis. Cellular and Molecular Life Sciences, 79, Article No. 272. https://doi.org/10.1007/s00018-022-04286-2 |
| [18] | Mageswari, R., Sridhar, M.G., Nandeesha, H., Parameshwaran, S. and Vinod, K.V. (2018) Irisin and Visfatin Predicts Severity of Diabetic Nephropathy. Indian Journal of Clinical Biochemistry, 34, 342-346. https://doi.org/10.1007/s12291-018-0749-7 |
| [19] | Wang, X., Zhang, S. and Li, Z. (2023) Adipokines in Glucose and Lipid Metabolism. Adipocyte, 12, Article ID: 2202976. https://doi.org/10.1080/21623945.2023.2202976 |
| [20] | Liu, J.J., Liu, S., Wang, J.X., Pek, S.L.T. and Lee, J. (2023) Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients with Type 2 Diabetes. Diabetes Care, 46, 408-415. |
| [21] | Duran-Salgado, M.B. (2014) Diabetic Nephropathy and Inflammation. World Journal of Diabetes, 5, 393-398. https://doi.org/10.4239/wjd.v5.i3.393 |
| [22] | Kojta, I., Chacińska, M. and B？achnio-Zabielska, A. (2020) Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance. Nutrients, 12, Article 1305. https://doi.org/10.3390/nu12051305 |
| [23] | Kahn, C.R., Wang, G. and Lee, K.Y. (2019) Altered Adipose Tissue and Adipocyte Function in the Pathogenesis of Metabolic Syndrome. Journal of Clinical Investigation, 129, 3990-4000. https://doi.org/10.1172/jci129187 |
| [24] | Helmy, M., Hamdy, N. and El Ghaffar, N. (2021) Connection Between the Plasma Level of Apelin and Diabetic Nephropathy in Type 2 Diabetic Patients. A Case Control Study. Indian Journal of Endocrinology and Metabolism, 25, 418-426. https://doi.org/10.4103/ijem.ijem_300_21 |
| [25] | 王晓艳, 魏枫, 王玮, 等. 血清Asprosin、Spexin水平与2型糖尿病并内脏型肥胖的相关性研究[J]. 中国全科医学, 2021, 24(36): 4623-4627. |
| [26] | 王琦, 翟爱华, 刘玉林, 等. Apelin在糖尿病和糖尿病微血管病变中作用的研究进展[J]. 中国老年学杂志, 2023, 43(21): 5362-5366. |
| [27] | 刘书苑, 张岩, 马红, 等. 新诊断2型糖尿病患者血清Pannexin-1、Apelin、RBP4、VEGF水平与糖脂代谢和胰岛素抵抗的关系研究[J]. 现代生物医学进展, 2020, 20(23): 4492-4496. https://doi.org/10.13241/j.cnki.pmb.2020.23.020 |
| [28] | 张坤. 脂肪因子分泌和炎症微环境交互作用驱动肥胖脂肪组织胰岛素抵抗的机制研究[D]: [博士学位论文]. 北京: 北京协和医学院, 2021. https://doi.org/10.27648/d.cnki.gzxhu.2021.000542 |
| [29] | 王萍, 邵丽燕, 江政松, 等. 脂肪因子Apelin与asprosin在糖尿病肾病中的表达及临床意义[J]. 医疗装备, 2023, 36(1): 45-46, 49. |
| [30] | Li, M., Fan, R., Peng, X., Huang, J., Zou, H., Yu, X., Yang, Y., Shi, X. and Ma, D. (2021) Association of ANGPTL8 and Resistin with Diabetic Nephropathy in Type 2 Diabetes Mellitus. Frontiers in Endocrinology, 12, Article 695750. https://doi.org/10.3389/fendo.2021.695750 |
| [31] | Kawai, T., Autieri, M.V. and Scalia, R. (2021) Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity. American Journal of Physiology-Cell Physiology, 320, C375-C391. https://doi.org/10.1152/ajpcell.00379.2020 |
| [32] | 王永军, 胡现斌, 张云, 等. 血清抵抗素、脂联素及IGF-1水平与糖尿病肾病的相关性分析[J]. 临床合理用药杂志, 2015, 8(4): 165, 167. https://doi.org/10.15887/j.cnki.13-1389/r.2015.04.100 |
| [33] | Clemente-Suárez, V.J., Redondo-Flórez, L., Beltrán-Velasco, A.I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C.C. and Tornero-Aguilera, J.F. (2023) The Role of Adipokines in Health and Disease. Biomedicines, 11, Article 1290. https://doi.org/10.3390/biomedicines11051290 |
