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Pharmacy Information 2024
能量代谢调控γδT细胞活化的研究进展
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Abstract:
代谢重编程与T细胞的发育、存活、活化及分化密切相关。T细胞被激活后，对维持细胞生长、增殖以及发挥作用所需的能量增加，需要通过重构细胞代谢来满足。γδT细胞作为T细胞的一种亚群，在自身免疫性疾病和肿瘤中发挥重要作用，已成为近年来的研究热点。本文简要综述脂质代谢、氧化磷酸化、谷氨酰胺代谢和糖酵解在调控γδT细胞活化中的参与和重要性，为构建针对其活化相关疾病的治疗策略提供思路。
Metabolic reprogramming is closely associated with the development, survival, activation, and differentiation of T cells. Upon activation, T cells require increased energy to sustain cell growth, proliferation, and effector functions, all of which need the reprogramming of cellular metabolism. γδT cells, as a subset of T cells, have emerged as a research focus in recent years due to their significant roles in autoimmune diseases and cancer. This article briefly reviews the involvement and importance of lipid metabolism, oxidative phosphorylation, glutamine metabolism, and glycolysis in regulating the activation of γδT cells, providing insights for developing therapeutic strategies targeting diseases associated with γδT cell activation.
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