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线粒动力学在射血分数保留型心衰中的研究进展
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Abstract:
射血分数保留型心衰(HFpEF)作为临床上最常见的心血管疾病之一，是导致人类死亡的主要原因。据统计，HFpEF患者的年死亡率约为10%~20%。HFpEF不仅严重影响患者的生活质量，还给家庭和社会带来巨大的经济负担。近年来，研究发现，HFpEF患者的心肌细胞中存在线粒体稳态失衡现象。线粒体形态和功能的改变导致能量代谢障碍，进而加剧了心肌细胞的损伤。因此，进一步探索心肌线粒体稳态的调节机制及其与HFpEF的关系，可以为HFpEF的发病机理提供新的认识，并为寻找新的治疗方法和靶点提供理论基础。
Heart Failure with Preserved Ejection Fraction (HFpEF), as one of the most common cardiovascular diseases in clinic, is the main cause of human death. According to statistics, the annual mortality of HFpEF patients is about 10%-20%. HFpEF not only seriously affects the quality of life of patients, but also brings huge economic burden to families and society. In recent years, mitochondrial homeostasis imbalance has been found in cardiac myocytes of HFpEF patients. The changes of mitochondrial morphology and function lead to the disturbance of energy metabolism, which aggravates the damage of myocardial cells. Therefore, to further explore the regulation mechanism of myocardial mitochondria homeostasis and its relationship with HFpEF can provide new understanding of the pathogenesis of HFpEF and provide a theoretical basis for finding new therapeutic methods and targets.
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