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慢性阻塞性肺疾病并发骨质疏松症的研究进展
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Abstract:
慢性阻塞性肺疾病(COPD)是一种异质性的气道疾病并且常伴全身炎症反应、恶病质、肌肉功能障碍和骨质疏松症等显著的肺外表现，大部分患者就诊时伴有骨质疏松或骨量减少，COPD患者中存在的低氧血症、炎症反应、吸烟、衰弱、维生素D缺乏及糖皮质激素的长期使用等危险因素都可以导致骨质疏松症的发生；而骨质疏松症引起的骨折不仅导致COPD患者的生活质量明显下降，原发肺部疾病加重。基于此，本文从其发病的危险因素及发病机制的研究进展进行阐述，以期为其预防与治疗提供思路。
Chronic obstructive pulmonary disease (COPD) is a heterogeneous airway disease often accompanied by significant extrapulmonary manifestations such as systemic inflammation, cachexia, muscle dysfunction, and osteoporosis. Approximately 50%~70% of COPD patients are diagnosed with osteoporosis or reduced bone mass. Risk factors such as hypoxemia, inflammation, smoking, frailty, vitamin D deficiency, and long-term use of glucocorticoids in COPD patients can all lead to the occurrence of osteoporosis; The fractures caused by osteoporosis not only lead to a significant decrease in the quality of life of COPD patients, but also worsen the primary lung disease. Based on this, this article elaborates on the research progress of its risk factors and pathogenesis, in order to provide ideas for its prevention and treatment.
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