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甘草防治心血管疾病的机制研究进展
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Abstract:
心血管疾病是目前全球最重要的公共卫生问题之一，居于我国城乡居民死亡构成比中的首位，目前治疗以西药为主，但常出现较多不良反应，预后欠佳。甘草，豆科甘草属多年草本植物，其内含有甘草素、甘草苷、甘草酸、甘草查耳酮A等多种活性成分。通过对已有研究进行综述，发现甘草及其活性成分具有保护心肌细胞、恢复心肌能量、保护血管内皮等作用，且传统中药治疗具有多靶点、多途径的优势，安全性较高，其主要通过减轻氧化应激、抗炎、改善线粒体功能等作用机制发挥功用。目前，甘草治疗心血管疾病方面已有诸多研究并取得一定成果，本文旨在总结近些年甘草及其活性成分治疗心血管疾病的相关机制研究，以期为甘草作为心血管疾病治疗药物提供理论依据，也为甘草作用机制的进一步研究提供参考。
Cardiovascular disease is one of the most important public health problems in the world, which ranks first in the mortality ratio of urban and rural residents in China. Western medicine is the main treatment at present, but there are often many adverse reactions and poor prognosis. Licorice, Leguminosae licorice is a perennial herb, which contains glycyrrhizin, glycyrrhizin, glycyrrhizic acid, licorice chalcone An and other active ingredients. Through the review of existing studies, it is found that licorice and its active components can protect cardiomyocytes, restore myocardial energy and protect vascular endothelium, and traditional Chinese medicine has the advantages of multi-targets, multi-pathways and high safety. It works mainly by reducing oxidative stress, anti-inflammation, improving mitochondrial function and so on. At present, there have been many studies on licorice in the treatment of cardiovascular diseases and some achievements have been made. The purpose of this paper is to summarize the related mechanisms of licorice and its active components in the treatment of cardiovascular diseases in recent years. It is expected to provide a theoretical basis for licorice as a cardiovascular disease treatment drug, and also provide a reference for further study of the mechanism of action of licorice.
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