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脑红蛋白抗氧化应激机制和临床应用
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Abstract:
脑红蛋白又称神经球蛋白(Neuroglobin, NGB)，是一种新型的携氧蛋白，主要存在于大脑的神经元中，在大脑缺血和氧化应激(Oxidative Stress, OS)造成的神经元死亡过程中起着重要作用，可通过改善线粒体的功能来减轻OS反应，此外，还具有直接清除活性氧(Reactive Oxygen Species, ROS)自由基及活性氮(Reactive Nitrogen Species, RNS)自由基、激活细胞生存信号、阻止神经细胞凋亡等作用，是一种内源性的抗OS损害的神经保护分子。本文在探索NGB抗OS的作用机制的基础上，对多种损害神经细胞的疾病在自我恢复过程中NGB的作用相关研究进行综述，以期为临床治疗此类疾病提供帮助。
Cerebroglobin, also known as neuroglobin (NGB), is a novel oxygen-carrying protein that is mainly found in neurons of the brain and plays an important role in neuronal death caused by ischemia and oxidative stress. In addition, it is an endogenous neuroprotective molecule against OS damage, as it directly scavenges reactive oxygen species (ROS) and reactive nitrogen species (RNS) radicals, activates cell survival signals and prevents neuronal apoptosis. Based on exploring the mechanism of NGB’s anti-OS action, this article reviews the relevant studies on the role of NGB in the self-recovery process of a variety of diseases that damage nerve cells, in order to provide help for the clinical treatment of such diseases.
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