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肝移植术后早期高BNP的研究进展
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Abstract:
肝移植已成为终末期肝病最有效治疗方式。但由于手术本身的特点、术前患者的基础状况较差且肝功能失代偿时间长容易造成术后易并发心血管系统的并发症并影响全身各器官功能进而影响预后。B型利钠肽(BNP)是心力衰竭的诊断标志物，术后早期BNP的升高可能会带来受者的急性心力衰竭。本文就肝移植术后早期BNP增加的危险因素及临床意义、肝移植受者心脏风险的预测及围术期管理进行综述。
Liver transplantation has become the most effective treatment for end-stage liver disease. However, due to the characteristics of the operation itself, the poor basic condition of the patients before operation and the long time of liver decompensation, it is easy to cause postoperative cardiovascular complications and affect the function of organs in the whole body, thus affecting the prognosis. B-type natriuretic peptide (BNP) is a diagnostic marker of heart failure, and the elevation of BNP in the early postoperative period may bring about acute heart failure in the recipient. This article reviews the risk factors and clinical significance of increased BNP in the early period after liver transplantation, and the prediction and perioperative management of cardiac risk in liver transplantation recipients.
| [1] | Toussaint, A., Weiss, E., Khoy-Ear, L., et al. (2016) Prognostic Value of Preoperative Brain Natriuretic Peptide Serum Levels in Liver Transplantation. Transplantation, 100, 819-824. https://doi.org/10.1097/TP.0000000000001077 |
| [2] | Sharma, S., Sonny, A., Dalia, A.A., et al. (2020) Acute Heart Failure after Liver Transplantation: A Narrative Review. Clinical Transplantation, 34, e14079. https://doi.org/10.1111/ctr.14079 |
| [3] | Konerman, M.A., Fritze, D., Weinberg, R.L., et al. (2017) Incidence of and Risk Assessment for Adverse Cardiovascular Outcomes after Liver Transplantation. Transplantation, 101, 1645-1657. https://doi.org/10.1097/TP.0000000000001710 |
| [4] | Koshy, A.N., Gow, P.J., Han, H.C., et al. (2021) Sudden Cardiac Death Following Liver Transplantation: Incidence, Trends and Risk Predictors. International Journal of Cardiology, 327, 171-174. https://doi.org/10.1016/j.ijcard.2020.11.038 |
| [5] | Piek, A., Du, W., De Boer, R.A., et al. (2018) Novel Heart Failure Biomarkers: Why Do We Fail to Exploit Their Potential? Critical Reviews in Clinical Laboratory Sciences, 55, 246-263. https://doi.org/10.1080/10408363.2018.1460576 |
| [6] | York, M.K., Gupta, D.K., Reynolds, C.F., et al. (2018) B-Type Natriuretic Peptide Levels and Mortality in Patients with and without Heart Failure. Journal of the American College of Cardiology, 71, 2079-2088. https://doi.org/10.1016/j.jacc.2018.02.071 |
| [7] | Chahal, D., Yau, A., Casciato, P., et al. (2019) B-Type Peptides to Predict Post-Liver Transplant Mortality: Systematic Review and Meta-Analysis. Canadian Liver Journal, 2, 4-18. https://doi.org/10.3138/canlivj.2018-0014 |
| [8] | Chung, H.S., Woo, A., Chae, M.S., et al. (2021) Combined B-Type Natriuretic Peptide as Strong Predictor of Short-Term Mortality in Patients after Liver Transplantation. International Journal of Medical Sciences, 18, 2500-2509. https://doi.org/10.7150/ijms.54202 |
| [9] | Scarlatescu, E., Marchenko, S.P. and Tomescu, D.R. (2020) Cirrhotic Cardiomyopathy—A Veiled Threat. Cardiology in Review, 30, 80-89. https://doi.org/10.1097/CRD.0000000000000377 |
| [10] | Kaur, H. and Premkumar, M. (2022) Diagnosis and Management of Cirrhotic Cardiomyopathy. Journal of Clinical and Experimental Hepatology, 12, 186-199. https://doi.org/10.1016/j.jceh.2021.08.016 |
| [11] | Fede, G., Privitera, G., Tomaselli, T., et al. (2015) Cardiovascular Dysfunction in Patients with Liver Cirrhosis. Annals of Gastroenterology, 28, 31-40. |
| [12] | M？ller, S. and Bendtsen, F. (2015) Cirrhotic Multiorgan Syndrome. Digestive Diseases and Sciences, 60, 3209-3225. https://doi.org/10.1007/s10620-015-3752-3 |
| [13] | M？ller, S., Danielsen, K.V., Wiese, S., et al. (2019) An Update on Cirrhotic Cardiomyopathy. Expert Review of Gastroenterology & Hepatology, 13, 497-505. https://doi.org/10.1080/17474124.2019.1587293 |
| [14] | Feng, A.C., Fan, H.L., Chen, T.W., et al. (2014) Hepatic Hemodynamic Changes during Liver Transplantation: A Review. World Journal of Gastroenterology, 20, 11131-11141. https://doi.org/10.3748/wjg.v20.i32.11131 |
| [15] | 李文磊, 栗光明. 肝移植受者术前心脏疾病风险评估的现状及展望[J]. 器官移植, 2023, 14(4): 605-611. |
| [16] | Aggarwal, S., Kang, Y., Freeman, J.A., et al. (1987) Postreperfusion Syndrome: Cardiovascular Collapse Following Hepatic Reperfusion during Liver Transplantation. Transplantation Proceedings, 19, 54-55. |
| [17] | Feltracco, P., Barbieri, S., Carollo, C., et al. (2019) Early Circulatory Complications in Liver Transplant Patients. Transplantation Reviews, 33, 219-230. https://doi.org/10.1016/j.trre.2019.06.005 |
| [18] | Ma, Z. and Lee, S.S. (1996) Cirrhotic Cardiomyopathy: Getting to the Heart of the Matter. Hepatology, 24, 451-459. https://doi.org/10.1002/hep.510240226 |
| [19] | Beltrami, M., Palazzuoli, A., Ruocco, G., et al. (2016) The Predictive Value of Plasma Biomarkers in Discharged Heart Failure Patients: The Role of Plasma BNP. Minerva Cardioangiologica, 64, 147-156. |
| [20] | Moroni, F., Gertz, Z. and Azzalini, L. (2021) Relief of Ischemia in Ischemic Cardiomyopathy. Current Cardiology Reports, 23, Article No. 80. https://doi.org/10.1007/s11886-021-01520-4 |
| [21] | Souki, F.G., Raveh, Y., Sancassani, R., et al. (2023) Characteristics, Risk Factors, and Outcome of New-Onset Systolic Heart Failure after Liver Transplantation: A Single-Center Cohort. Transplant Direct, 9, e1499. https://doi.org/10.1097/TXD.0000000000001499 |
| [22] | Diedrich, D.A., Findlay, J.Y., Harrison, B.A., et al. (2008) Influence of Coronary Artery Disease on Outcomes after Liver Transplantation. Transplantation Proceedings, 40, 3554-3557. https://doi.org/10.1016/j.transproceed.2008.08.129 |
| [23] | Plotkin, J.S., Scott, V.L., Pinna, A., et al. (1996) Morbidity and Mortality in Patients with Coronary Artery Disease Undergoing Orthotopic Liver Transplantation. Liver Transplant Surgery, 2, 426-430. https://doi.org/10.1002/lt.500020604 |
| [24] | Palazzuoli, A., Gennari, L., Calabria, P., et al. (2005) Relation of Plasma Brain Natriuretic Peptide Levels in Non-ST-Elevation Coronary Disease and Preserved Systolic Function to Number of Narrowed Coronary Arteries. The American Journal of Cardiology, 96, 1705-1710. https://doi.org/10.1016/j.amjcard.2005.07.094 |
| [25] | Snipelisky, D.F., Mcree, C., Seeger, K., et al. (2015) Coronary Interventions before Liver Transplantation Might Not Avert Postoperative Cardiovascular Events. Texas Heart Institute Journal, 42, 438-442. https://doi.org/10.14503/THIJ-14-4738 |
| [26] | Maisch, B. (2016) Alcoholic Cardiomyopathy: The Result of Dosage and Individual Predisposition. Herz, 41, 484-493. https://doi.org/10.1007/s00059-016-4469-6 |
| [27] | Movva, R. and Figueredo, V.M. (2013) Alcohol and the Heart: To Abstain or Not to Abstain? International Journal of Cardiology, 164, 267-276. https://doi.org/10.1016/j.ijcard.2012.01.030 |
| [28] | Guzzo-Merello, G., Cobo-Marcos, M., Gallego-Delgado, M., et al. (2014) Alcoholic Cardiomyopathy. World Journal of Cardiology, 6, 771-781. https://doi.org/10.4330/wjc.v6.i8.771 |
| [29] | Wang, C., Gao, H., Liu, W., et al. (2023) Alcoholic Cardiomyopathy in Patients with Alcoholic Liver Cirrhosis: A Study Across 10 Years. European Journal of Gastroenterology & Hepatology, 35, 600-603. https://doi.org/10.1097/MEG.0000000000002541 |
| [30] | Matyas, C., Varga, Z.V., Mukhopadhyay, P., et al. (2016) Chronic Plus Binge Ethanol Feeding Induces Myocardial Oxidative Stress, Mitochondrial and Cardiovascular Dysfunction, and Steatosis. American Journal of Physiology-Heart and Circulatory Physiology, 310, H1658-H1670. https://doi.org/10.1152/ajpheart.00214.2016 |
| [31] | Ballestri, S., Lonardo, A., Bonapace, S., et al. (2014) Risk of Cardiovascular, Cardiac and Arrhythmic Complications in Patients with Non-Alcoholic Fatty Liver Disease. World Journal of Gastroenterology, 20, 1724-1745. https://doi.org/10.3748/wjg.v20.i7.1724 |
| [32] | Bonapace, S., Perseghin, G., Molon, G., et al. (2012) Nonalcoholic Fatty Liver Disease Is Associated with Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes. Diabetes Care, 35, 389-395. https://doi.org/10.2337/dc11-1820 |
| [33] | Cosarderelioglu, C., Cosar, A.M., Gurakar, M., et al. (2016) Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature. Experimental and Clinical Transplantation, 14, 113-120. |
| [34] | Talwalkar, J.A., Swanson, K.L., Krowka, M.J., et al. (2011) Prevalence of Spontaneous Portosystemic Shunts in Patients with Portopulmonary Hypertension and Effect on Treatment. Gastroenterology, 141, 1673-1679. https://doi.org/10.1053/j.gastro.2011.06.053 |
| [35] | Krowka, M.J., Plevak, D.J., Findlay, J.Y., et al. (2000) Pulmonary Hemodynamics and Perioperative Cardiopulmonary-Related Mortality in Patients with Portopulmonary Hypertension Undergoing Liver Transplantation. Liver Transplantation, 6, 443-450. https://doi.org/10.1053/jlts.2000.6356 |
| [36] | Swanson, K.L., Wiesner, R.H. and Krowka, M.J. (2005) Natural History of Hepatopulmonary Syndrome: Impact of Liver Transplantation. Hepatology, 41, 1122-1129. https://doi.org/10.1002/hep.20658 |
| [37] | Saab, S., Landaverde, C., Ibrahim, A.B., et al. (2006) The MELD Score in Advanced Liver Disease: Association with Clinical Portal Hypertension and Mortality. Experimental and Clinical Transplantation, 4, 395-399. |
| [38] | Abe, S., Yoshihisa, A., Takiguchi, M., et al. (2014) Liver Dysfunction Assessed by Model for End-Stage Liver Disease Excluding INR (MELD-XI) Scoring System Predicts Adverse Prognosis in Heart Failure. PLOS ONE, 9, e100618. https://doi.org/10.1371/journal.pone.0100618 |
| [39] | Kwon, H.M., Moon, Y.J., Kim, K.S., et al. (2021) Prognostic Value of B-Type Natriuretic Peptide in Liver Transplant Patients: Implication in Posttransplant Mortality. Hepatology, 74, 336-350. https://doi.org/10.1002/hep.31661 |
| [40] | Hendrickson, J.E., Roubinian, N.H., Chowdhury, D., et al. (2016) Incidence of Transfusion Reactions: A Multicenter Study Utilizing Systematic Active Surveillance and Expert Adjudication. Transfusion, 56, 2587-2596. https://doi.org/10.1111/trf.13730 |
| [41] | Hernandez-Guerra, M., Lopez, E., Bellot, P., et al. (2006) Systemic Hemodynamics, Vasoactive Systems, and Plasma Volume in Patients with Severe Budd-Chiari Syndrome. Hepatology, 43, 27-33. https://doi.org/10.1002/hep.20990 |
| [42] | Mueller, C., Mcdonald, K., De Boer, R.A., et al. (2019) Heart Failure Association of the European Society of Cardiology Practical Guidance on the Use of Natriuretic Peptide Concentrations. European Journal of Heart Failure, 21, 715-731. https://doi.org/10.1002/ejhf.1494 |
| [43] | European Association for the Study of the Liver (2018) EASL Clinical Practice Guidelines for the Management of Patients with Decompensated Cirrhosis. Journal of Hepatology, 69, 406-460. https://doi.org/10.1016/j.jhep.2018.03.024 |
| [44] | Izzy, M., Fortune, B.E., Serper, M., et al. (2022) Management of Cardiac Diseases in Liver Transplant Recipients: Comprehensive Review and Multidisciplinary Practice-Based Recommendations. American Journal of Transplantation, 22, 2740-2758. https://doi.org/10.1111/ajt.17049 |
| [45] | Lim, W.H., Chew, N.W., Quek, J., et al. (2022) Echocardiographic Assessment of Cardiovascular Function and Clinical Outcomes in Liver Transplant Recipients. Clinical Transplantation, 36, e14793. https://doi.org/10.1111/ctr.14793 |
| [46] | Kaski, J.C., Crea, F., Gersh, B.J., et al. (2018) Reappraisal of Ischemic Heart Disease. Circulation, 138, 1463-1480. https://doi.org/10.1161/CIRCULATIONAHA.118.031373 |
| [47] | Patel, S.S., Nabi, E., Guzman, L., et al. (2018) Coronary Artery Disease in Decompensated Patients Undergoing Liver Transplantation Evaluation. Liver Transplantation, 24, 333-342. https://doi.org/10.1002/lt.25012 |
| [48] | 吉晓琳, 张欢, 黄佳鹏. 经食道心脏超声在肝移植手术中的应用[J]. 麻醉安全与质控, 2020, 4(1): 53-57. |
| [49] | Mazilescu, L.I., Bezinover, D., Paul, A., et al. (2018) Unrecognized Esophageal Perforation after Liver Transplantation. Journal of Cardiothoracic and Vascular Anesthesia, 32, 1407-1410. https://doi.org/10.1053/j.jvca.2017.10.035 |
| [50] | Moguilevitch, M., Rufino, M., Leff, J., et al. (2015) Novel Approach for Heart Failure Treatment after Liver Transplantation. Liver Transplantation, 21, 1103-1104. https://doi.org/10.1002/lt.24162 |
| [51] | Palanisamy, A.P., Nadig, S.N., Chedister, G.R., et al. (2017) Use of Intra-Aortic Counterpulsation in Cardiogenic Shock Post-Liver Transplantation. Clinical Transplantation, 31, e13002. https://doi.org/10.1111/ctr.13002 |
| [52] | Justo, I., Marcacuzco, A., Caso, ó., et al. (2023) Risk Factors of Massive Blood Transfusion in Liver Transplantation: Consequences and a New Index for Prediction Including the Donor. Cirugía Espa？ola (English Edition), 101, 684-692. https://doi.org/10.1016/j.cireng.2023.09.002 |
| [53] | Galiè, N., Mclaughlin, V.V., Rubin, L.J., et al. (2019) An Overview of the 6th World Symposium on Pulmonary Hypertension. European Respiratory Journal, 53, Article 1802148. https://doi.org/10.1183/13993003.02148-2018 |
| [54] | Preston, I.R., Burger, C.D., Bartolome, S., et al. (2020) Ambrisentan in Portopulmonary Hypertension: A Multicenter, Open-Label Trial. The Journal of Heart and Lung Transplantation, 39, 464-472. https://doi.org/10.1016/j.healun.2019.12.008 |
