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基于内质网应激探究中医药防治心力衰竭
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Abstract:
近年来，心力衰竭的患病人数逐年增加，对于人们生活质量产生严重影响，研究发现内质网应激在心力衰竭的发生发展中产生重要作用，一方面，内质网应激可以促进心血管疾病向心力衰竭的转变；另一方面，内质网应激会加重心力衰竭的严重程度。中医药在治疗心力衰竭、改善患者预后方面具有显著疗效，对于内质网应激的调控也有显著作用，可以通过改善其相应感受器通路的表达来缓解内质网应激，下调未折叠蛋白反应，减少心肌细胞凋亡，延缓心力衰竭进程。
In recent years, the number of patients with heart failure has increased year by year, which has a serious impact on people’s quality of life, and studies have found that endoplasmic reticulum stress plays an important role in the occurrence and development of heart failure. On the one hand, endoplasmic reticulum stress can promote the transition of cardiovascular disease to heart failure, on the other hand, endoplasmic reticulum stress can exacerbate the severity of heart failure. Traditional Chinese medicine (TCM) has significant efficacy in the treatment of heart failure and the prognosis of patients, and also plays a significant role in the regulation of endoplasmic reticulum stress, which can alleviate endoplasmic reticulum stress by improving the expression of its corresponding receptor pathways, down-regulate the unfolded protein response, reduce cardiomyocyte apoptosis, and delay the process of heart failure.
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