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探讨METTL3在Kummell疾病中的生物学作用
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Abstract:
N6-甲基腺苷(m6A)在真核生物中最丰富的mRNA修饰，其甲基转移酶样3 (METTL3)是最重要的催化亚基。近年研究表明，METTL3在多种疾病中起着关键作用，其中骨质疏松的发生中成骨细胞及破骨细胞相关的RNA修饰均受到METTL3的调节。成骨细胞及破骨细胞在Kummell发生中有生物学相关性，而METTL3在Kummell中的表达情况以及临床意义尚未得到强调。故在这里，我们总结了METTL3的表达与Kummell病及其他骨骼疾病的发生发展中的关联性，为Kummell疾病的发生进展机制研究提供理论基础和研究思路。
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, and its methyltransferase-like 3 (METTL3) is the most important catalytic subunit. Recent studies have shown that METTL3 plays a key role in a variety of diseases, among which the RNA modification associated with osteoporoblasts and osteoclasts is regulated by METTL3 in the occurrence of osteoporosis. Osteoblasts and osteoclasts are biologically related in the occurrence of Kummell, while the expression and clinical significance of METTL3 in Kummell have not been emphasized. Therefore, we summarize the correlation between the expression of METTL3 and the occurrence and development of Kummell’s disease and other skeletal diseases, so as to provide a theoretical basis and research ideas for the study of the occurrence and progression mechanism of Kummell’s disease.
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