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脑肿瘤患儿的神经认知功能预后
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Abstract:
脑肿瘤(Brain Tumor, BT)在儿童中是仅次于白血病的第二大常见恶性肿瘤,医学诊断和治疗技术的进步提高了生存率,但如何有效改善认知功能预后仍然是一个挑战。近年来对脑肿瘤患儿认知功能预后的研究不断深入,本文对以上研究进行系统回顾,探索BT对儿童认知功能的影响、相关危险因素以及干预措施,以期改善BT患儿的认知功能和生活质量。
Brain tumors are the second most common malignant tumors in children after leukemia. Advances in medical diagnosis and treatment have improved survival rates, but effectively improving cognitive function prognosis remains a challenge. In recent years, research into the prognosis of cognitive function in children with brain tumors has deepened. This article systematically reviews the above studies, exploring the impact of brain tumors on cognitive function in children, related risk factors, and intervention measures, with the aim of improving the cognitive function and quality of life of children with brain tumors.
[1] | 马杰. 我国儿童中枢神经系统肿瘤诊治现状[J]. 中华神经外科疾病研究杂志, 2018, 17(3): 193-197. |
[2] | Steliarova-Foucher, E., Colombet, M., Ries, L.A.G., et al. (2017) International Incidence of Childhood Cancer, 2001-10: A Population-Based Registry Study. Lancet Oncology, 18, 719-731. https://doi.org/10.1016/S1470-2045(17)30186-9 |
[3] | Quon, J.L., Bala, W., Chen, L.C., et al. (2020) Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study. AJNR American Journal of Neuroradiology, 41, 1718-1725. https://doi.org/10.3174/ajnr.A6704 |
[4] | 余建忠, 施伟, 赵瑞, 等. 儿童髓母细胞瘤的临床特点及预后相关因素分析[J]. 临床小儿外科杂志, 2020, 19(3): 236-240, 247. |
[5] | Millard, N.E. and De Braganca, K.C. (2016) Medulloblastoma. Journal of Child Neurology, 31, 1341-1353. https://doi.org/10.1177/0883073815600866 |
[6] | 黄怀忠. 髓母细胞瘤的诊治研究新进展[J]. 国际神经病学神经外科学杂志, 2010, 37(3): 241-246. |
[7] | Weil, A.G., Wang, A.C., Westwick, H.J., et al. (2017) Survival in Pediatric Medulloblastoma: A Population-Based Observational Study to Improve Prognostication. Journal of Neuro-Oncology, 132, 99-107. https://doi.org/10.1007/s11060-016-2341-4 |
[8] | Macartney, G., Harrison, M.B., VanDenKerkhof, E., Stacey, D. and McCarthy, P. (2014) Quality of Life and Symptoms in Pediatric Brain Tumor Survivors: A Systematic Review. Journal of Pediatric Oncology Nursing, 31, 65-77. https://doi.org/10.1177/1043454213520191 |
[9] | Mulhern, R.K., Merchant, T.E., Gajjar, A., et al. (2004) Late Neurocognitive Sequelae in Survivors of Brain Tumours in Childhood. Lancet Oncology, 5, 399-408. https://doi.org/10.1016/S1470-2045(04)01507-4 |
[10] | Janzen, L.A. (2016) Long-Term Neurocognitive and Functional Effects of Treatment for Childhood Acute Lymphoblastic Leukaemia. Lancet Psychiatry, 3, 912-913. https://doi.org/10.1016/S2215-0366(16)30278-4 |
[11] | Armstrong, G.T., Jain, N., Liu, W., et al. (2010) Region-Specific Radiotherapy and Neuropsychological Outcomes in Adult Survivors of Childhood CNS Malignancies. Neuro-Oncology, 12, 1173-1186. https://doi.org/10.1093/neuonc/noq104 |
[12] | Bloom, H.J., Wallace, E.N. and Henk, J.M. (1969) The Treatment and Prognosis of Medulloblastoma in Children: A Study of 82 Verified Cases. The American Journal of Roentgenology Radium Therapy and Nuclear Medicine, 105, 43-62. https://doi.org/10.2214/ajr.105.1.43 |
[13] | Palmer, S.L. (2008) Neurodevelopmental Impact on Children Treated for Medulloblastoma: A Review and Proposed Conceptual Model. Developmental Disabilities Research Reviews, 14, 203-210. https://doi.org/10.1002/ddrr.32 |
[14] | Saury, J.M. and Emanuelson, I. (2011) Cognitive Consequences of the Treatment of Medulloblastoma among Children. Pediatric Neurology, 44, 21-30. https://doi.org/10.1016/j.pediatrneurol.2010.07.004 |
[15] | Hanzlik, E., Woodrome, S.E., Abdel-Baki, M., et al. (2015) A Systematic Review of Neuropsychological Outcomes Following Posterior Fossa Tumor Surgery in Children. Child’s Nervous System, 31, 1869-1875. https://doi.org/10.1007/s00381-015-2867-3 |
[16] | Merchant, T.E., Schreiber, J.E., Wu, S., et al. (2014) Critical Combinations of Radiation Dose and Volume Predict Intelligence Quotient and Academic Achievement Scores after Craniospinal Irradiation in Children with Medulloblastoma. International Journal of Radiation Oncology, Biology, Physics, 90, 554-561. https://doi.org/10.1016/j.ijrobp.2014.06.058 |
[17] | Palmer, S.L., Goloubeva, O., Reddick, W.E., et al. (2001) Patterns of Intellectual Development among Survivors of Pediatric Medulloblastoma: A Longitudinal Analysis. Journal of Clinical Oncology, 19, 2302-2308. https://doi.org/10.1200/JCO.2001.19.8.2302 |
[18] | Kieffer-Renaux, V., Bulteau, C., Grill, J., et al. (2000) Patterns of Neuropsychological Deficits in Children with Medulloblastoma According to Craniospatial Irradiation Doses. Developmental Medicine & Child Neurology, 42, 741-745. https://doi.org/10.1111/j.1469-8749.2000.tb00036.x |
[19] | Chevignard, M., Camara-Costa, H., Doz, F., et al. (2017) Core Deficits and Quality of Survival after Childhood Medulloblastoma: A Review. Neuro-Oncology Practice, 4, 82-97. https://doi.org/10.1093/nop/npw013 |
[20] | Feldman, H.M. (2019) The Importance of Language-Learning Environments to Child Language Outcomes. Pediatrics, 144, e20192157. https://doi.org/10.1542/peds.2019-2157 |
[21] | Stavinoha, P.L., Askins, M.A., Powell, S.K., Pillay Smiley, N. and Robert, R.S. (2018) Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Bioengineering, 5, Article 73. https://doi.org/10.3390/bioengineering5030073 |
[22] | Mabbott, D.J., Spiegler, B.J., Greenberg, M.L., et al. (2005) Serial Evaluation of Academic and Behavioral Outcome after Treatment with Cranial Radiation in Childhood. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 23, 2256-2263. https://doi.org/10.1200/JCO.2005.01.158 |
[23] | Corti, C., Poggi, G., Massimino, M., et al. (2018) Visual Perception and Spatial Transformation of the Body in Children and Adolescents with Brain Tumor. Neuropsychologia, 120, 124-136. https://doi.org/10.1016/j.neuropsychologia.2018.10.012 |
[24] | Conklin, H.M., Li, C., Xiong, X., et al. (2008) Predicting Change in Academic Abilities after Conformal Radiation Therapy for Localized Ependymoma. Journal of Clinical Oncology, 26, 3965-3970. https://doi.org/10.1200/JCO.2007.15.9970 |
[25] | Mulhern, R.K., Reddick, W.E., Palmer, S.L., et al. (1999) Neurocognitive Deficits in Medulloblastoma Survivors and White Matter Loss. Annals of Neurology, 46, 834-841. https://doi.org/10.1002/1531-8249(199912)46:6<834::AID-ANA5>3.0.CO;2-M |
[26] | Hardy, K.K., Willard, V.W., Allen, T.M., et al. (2013) Working Memory Training in Survivors of Pediatric Cancer: A Randomized Pilot Study. Psycho-Oncology, 22, 1856-1865. https://doi.org/10.1002/pon.3222 |
[27] | Reeves, C.B., Palmer, S.L., Reddick, W.E., et al. (2006) Attention and Memory Functioning among Pediatric Patients with Medulloblastoma. Journal of Pediatric Psychology, 31, 272-280. https://doi.org/10.1093/jpepsy/jsj019 |
[28] | Brière, M.E., Scott, J.G., McNall-Knapp, R.Y., et al. (2008) Cognitive Outcome in Pediatric Brain Tumor Survivors: Delayed Attention Deficit at Long-Term Follow-Up. Pediatric Blood & Cancer, 50, 337-340. https://doi.org/10.1002/pbc.21223 |
[29] | King, T.Z., Fennell, E.B., Williams, L., et al. (2004) Verbal Memory Abilities of Children with Brain Tumors. Child Neuropsychology, 10, 76-88. https://doi.org/10.1080/09297040490911096 |
[30] | Edelstein, K., Spiegler, B.J., Fung, S., et al. (2011) Early Aging in Adult Survivors of Childhood Medulloblastoma: Long-Term Neurocognitive, Functional, and Physical Outcomes. Neuro-Oncology, 13, 536-545. https://doi.org/10.1093/neuonc/nor015 |
[31] | Maddrey, A.M., Bergeron, J.A., Lombardo, E.R., et al. (2005) Neuropsychological Performance and Quality of Life of 10-Year Survivors of Childhood Medulloblastoma. Journal of Neuro-Oncology, 72, 245-253. https://doi.org/10.1007/s11060-004-3009-z |
[32] | Conklin, H.M., Reddick, W.E., Ashford, J., Ogg, S., Howard, S.C., Morris, E.B., Brown, R., Bonner, M., Christensen, R., Wu, S., Xiong, X. and Khan, R.B. (2010) Long-Term Efficacy of Methylphenidate in Enhancing Attention Regulation, Social Skills, and Academic Abilities of Childhood Cancer Survivors. Journal of Clinical Oncology, 28, 4465-4472. https://doi.org/10.1200/JCO.2010.28.4026 |
[33] | Wolfe, K.R., Madan-Swain, A. and Kana, R.K. (2012) Executive Dysfunction in Pediatric Posterior Fossa Tumor Survivors: A Systematic Literature Review of Neurocognitive Deficits and Interventions. Developmental Neuropsychology, 37, 153-175. https://doi.org/10.1080/87565641.2011.632462 |
[34] | Armstrong, C.L., Hunter, J.V., Ledakis, G.E., et al. (2002) Late Cognitive and Radiographic Changes Related to Radiotherapy: Initial Prospective Findings. Neurology, 59, 40-48. https://doi.org/10.1212/WNL.59.1.40 |
[35] | Koustenis, E., Hernáiz Driever, P., et al. (2016) Executive Function Deficits in Pediatric Cerebellar Tumor Survivors. European Journal of Paediatric Neurology, 20, 25-37. https://doi.org/10.1016/j.ejpn.2015.11.001 |
[36] | George, A.P., Kuehn, S.M., Vassilyadi, M., et al. (2003) Cognitive Sequelae in Children with Posterior Fossa Tumors. Pediatric Neurology, 28, 42-47. https://doi.org/10.1016/S0887-8994(02)00471-X |
[37] | Anderson, V., Spencer-Smith, M., Leventer, R., et al. (2009) Childhood Brain Insult: Can Age at Insult Help Us Predict Outcome? Brain, 132, 45-56. https://doi.org/10.1093/brain/awn293 |
[38] | Mulhern, R.K., Palmer, S.L., Reddick, W.E., et al. (2001) Risks of Young Age for Selected Neurocognitive Deficits in Medulloblastoma Are Associated with White Matter Loss. Journal of Clinical Oncology, 19, 472-479. https://doi.org/10.1200/JCO.2001.19.2.472 |
[39] | Desmond, J.E. and Fiez, J.A. (1998) Neuroimaging Studies of the Cerebellum: Language, Learning and Memory. Trends in Cognitive Sciences, 2, 355-362. https://doi.org/10.1016/S1364-6613(98)01211-X |
[40] | Hardy, K.K., Bonner, M.J., Willard, V.W., et al. (2008) Hydrocephalus as a Possible Additional Contributor to Cognitive Outcome in Survivors of Pediatric Medulloblastoma. Psycho-Oncology, 17, 1157-1161. https://doi.org/10.1002/pon.1349 |
[41] | Kao, G.D., Goldwein, J.W., Schultz, D.J., et al. (1994) The Impact of Perioperative Factors on Subsequent Intelligence Quotient Deficits in Children Treated for Medulloblastoma/Posterior Fossa Primitive Neuroectodermal Tumors. Cancer, 74, 965-971. https://doi.org/10.1002/1097-0142(19940801)74:3<965::AID-CNCR2820740328>3.0.CO;2-Z |
[42] | 戎宏涛, 岳树源, 惠旭辉. 小脑性缄默症[J]. 中华神经外科杂志, 2015, 31(1): 101-103. |
[43] | Siffert, J., Poussaint, T.Y., Goumnerova, L.C., et al. (2000) Neurological Dysfunction Associated with Postoperative Cerebellar Mutism. Journal of Neuro-Oncology, 48, 75-81. https://doi.org/10.1023/A:1006483531811 |
[44] | Miller, N.G., Reddick, W.E., Kocak, M., et al. (2010) Cerebellocerebral Diaschisis Is the Likely Mechanism of Postsurgical Posterior Fossa Syndrome in Pediatric Patients with Midline Cerebellar Tumors. AJNR American Journal of Neuroradiology, 31, 288-294. https://doi.org/10.3174/ajnr.A1821 |
[45] | Gudrunardottir, T., Sehested, A., Juhler, M., et al. (2011) Cerebellar Mutism: Definitions, Classification and Grading of Symptoms. Child’s Nervous System, 27, 1361-1363. https://doi.org/10.1007/s00381-011-1509-7 |
[46] | Lawrence, Y.R., Li, X.A., el Naqa, I., et al. (2010) Radiation Dose-Volume Effects in the Brain. International Journal of Radiation Oncology, Biology, Physics, 76, S20-S27. https://doi.org/10.1016/j.ijrobp.2009.02.091 |
[47] | Grill, J., Renaux, V.K., Bulteau, C., et al. (1999) Long-Term Intellectual Outcome in Children with Posterior Fossa Tumors According to Radiation Doses and Volumes. International Journal of Radiation Oncology, Biology, Physics, 45, 137-145. https://doi.org/10.1016/S0360-3016(99)00177-7 |
[48] | Moxon-Emre, I., Bouffet, E., Taylor, M.D., et al. (2014) Impact of Craniospinal Dose, Boost Volume, and Neurologic Complications on Intellectual Outcome in Patients with Medulloblastoma. Journal of Clinical Oncology, 32, 1760-1768. https://doi.org/10.1200/JCO.2013.52.3290 |
[49] | Palmer, S.L., Gajjar, A., Reddick, W.E., et al. (2003) Predicting Intellectual Outcome among Children Treated with 35-40 Gy Craniospinal Irradiation for Medulloblastoma. Neuropsychology, 17, 548-555. https://doi.org/10.1037/0894-4105.17.4.548 |
[50] | Nagel, B.J., Delis, D.C., Palmer, S.L., et al. (2006) Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma. Neuropsychology, 20, 105-112. https://doi.org/10.1037/0894-4105.20.1.105 |
[51] | Conklin, H.M., Ogg, R.J., Ashford, J.M., et al. (2015) Computerized Cognitive Training for Amelioration of Cognitive Late Effects among Childhood Cancer Survivors: A Randomized Controlled Trial. Journal of Clinical Oncology, 33, 3894-3902. https://doi.org/10.1200/JCO.2015.61.6672 |