以丹酚酸B为指标性成分的复方巴戟天健骨颗粒整体质量评价
Overall Quality Evaluation of Compound Morinda Jiangu Granules with Salvianolic Acid B as the Index Component

目的：通过复方巴戟天健骨颗粒中丹酚酸B质量控制研究，评价制剂质量。方法：色谱柱采用Sino Chrom ODS-BP (4.6 mm × 250 mm, 5 μm)，流动相乙腈-0.1%磷酸水，等度洗脱，体积流量1.2 mL？min？1，柱温30℃，检测波长286 nm。结果：丹酚酸B在考察的浓度范围内线性关系良好(r = 1.000)，线性范围为8.25~165.00 μg/mL，平均加样回收率为99.16%，RSD为1.52%。结论：该方法操作简便、准确、重复性好，可为复方巴戟天健骨颗粒质量控制提供实验依据。
Objective: To evaluate the quality of the preparation through the quality control study of salvianolic acid B in Compound Morinda Jiangu Granules. Methods: The chromatographic column adopted Sino Chrom ODS-BP (4.6 mm × 250 mm, 5 μm), and the mobile phase was acetonitrile-0.1% phosphoric acid water. Isocratic elution was used with a volume flow rate of 1.2 mL？min？1, a column tempera-ture of 30？C, and a detection wavelength of 286 nm. Results: Salvianolic acid B had a good linear re-lationship within the investigated concentration range (r = 1.000), the linear range was 8.25~165.00 μg/mL, the average recovery rate was 99.16%, and the RSD was 1.52%. Conclusion: This method is simple to operate, accurate and reproducible, and can provide experimental basis for quality control of Compound Morinda Jiangu Granules.