|
|
长链非编码RNA与肺癌预后关系研究进展
|
Abstract:
肺癌是全球最常见的癌症，发病率和死亡率高，严重影响人类健康和生命威胁。虽然近年来其治疗取得了一定进展，但非小细胞肺癌的5年生存率仍处于较低水平。长链非编码RNA (lncRNA)作为一种不能编码蛋白质的非编码RNA分子，在多种恶性肿瘤中异常表达，且与肿瘤的预后密切相关。因此，研究lncRNA在肺癌中的表达情况，寻找与非小细胞肺癌病情进展程度有关的生物学分子标志物，对改善患者预后具有重要临床意义。本文就已发现相关lncRNA与肺癌预后关系的研究进展作一综述。
Lung cancer is the most common cancer in the world, with high morbidity and mortality, seriously affecting human health and threatening life. Although its treatment has made some progress in re-cent years, the 5-year survival rate of non-small cell lung cancer is still low. Long non-coding RNA (lncRNA), as a non-coding RNA molecule that cannot encode protein, is abnormally expressed in a variety of malignant tumors and is closely related to tumor prognosis. Therefore, studying the ex-pression of lncRNA in lung cancer and searching for biological molecular markers related to the progression of NSCLC have important clinical significance for improving the prognosis of patients. In this review, we reviewed the research progress on the relationship between lncRNA and lung can-cer prognosis.
| [1] | Pawlak, K., Gabryel, P., Kujawska, A., Kasprzyk, M., Piwkowski, C., Kuffel, B. and Dyszkiewicz, W. (2018) Long-Term Results of Surgical Treatment of Non-Small Cell Lung Cancer in Patients over 75 Years of Age. Kardi-ochirugia i Torakochirurgia Polska, 15, 65-71. https://doi.org/10.5114/kitp.2018.76470 |
| [2] | Siegel, R.L., Miller, K.D. and Jemal, A. (2020) Cancer Statistics, 2020. CA: A Cancer Journal for Clinicians, 70, 7-30.
https://doi.org/10.3322/caac.21590 |
| [3] | Liu, X., Huang, G., Zhang, J., Zhang, L. and Liang, Z. (2020) Prognostic and Clinicopathological Significance of Long Noncoding RNA MALAT-1 Expression in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis. PLOS ONE, 15, e0240321. https://doi.org/10.1371/journal.pone.0240321 |
| [4] | Yu, H., Shen, Z.A., Zhou, Y.K. and Du, P.F. (2022) Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods. Current Gene Therapy, 22, 228-244.
https://doi.org/10.2174/1566523221666210712190718 |
| [5] | Li, X., Sun, D., Zhao, T. and Zhang, Z. (2020) Long Non-Coding RNA ROR Confers Arsenic Trioxide Resistance to HepG2 Cells by Inhibiting p53 Expression. European Journal of Pharmacology, 872, Article ID: 172982.
https://doi.org/10.1016/j.ejphar.2020.172982 |
| [6] | Wang, X., Lai, Q., He, J., Li, Q., Ding, J., Lan, Z., Gu, C., Yan, Q., Fang, Y., Zhao, X. and Liu, S. (2019) LncRNA SNHG6 Promotes Proliferation, Invasion and Migration in Colorec-tal Cancer Cells by Activating TGF-β/Smad Signaling Pathway via Targeting UPF1 and Inducing EMT via Regulation of ZEB1. International Journal of Medical Sciences, 16, 51-59. https://doi.org/10.7150/ijms.27359 |
| [7] | Sun, Z., Shao, B., Liu, Z., Dang, Q., Guo, Y., Chen, C., Guo, Y., Chen, Z., Liu, J., Hu, S., Yuan, W. and Zhou, Q. (2021) LINC01296/miR-141-3p/ZEB1-ZEB2 Axis Promotes Tumor Metastasis via Enhancing Epithelial-Mesenchymal Transi-tion Process. Journal of Cancer, 12, 2723-2734. https://doi.org/10.7150/jca.55626 |
| [8] | Chen, R., Manochakian, R., James, L., Azzouqa, A.G., Shi, H., Zhang, Y., Zhao, Y., Zhou, K. and Lou, Y. (2020) Emerging Therapeutic Agents for Advanced Non-Small Cell Lung Cancer. Journal of Hematology & Oncology, 13, Article No. 58. https://doi.org/10.1186/s13045-020-00881-7 |
| [9] | Li, Y., Zhang, H., Guo, J., Li, W., Wang, X., Zhang, C., Sun, Q. and Ma, Z. (2021) Downregulation of LINC01296 Suppresses Non-Small-Cell Lung Cancer via Targeting miR-143-3p/ATG2B. Acta Biochimica et Biophysica Sinica, 53, 1681-1690. https://doi.org/10.1093/abbs/gmab149 |
| [10] | Wang, C., Wang, L., Ding, Y., Lu, X., Zhang, G., Yang, J., Zheng, H., Wang, H., Jiang, Y. and Xu, L. (2017) LncRNA Structural Characteristics in Epigenetic Regulation. International Jour-nal of Molecular Sciences, 18, Article 2659.
https://doi.org/10.3390/ijms18122659 |
| [11] | Hao, L., Wu, W., Xu, Y., Chen, Y., Meng, C., Yun, J. and Wang, X. (2023) LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer. Molecules, 28, Article 2126. https://doi.org/10.3390/molecules28052126 |
| [12] | Sun, Y. and Ma, L. (2019) New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis. Cancers, 11, Article 216. https://doi.org/10.3390/cancers11020216 |
| [13] | Wang, D., Zhang, S., Zhao, M. and Chen, F. (2020) LncRNA MALAT1 Accelerates Non-Small Cell Lung Cancer Progression via Regulating miR-185-5p/MDM4 Axis. Cancer Medicine, 9, 9138-9149.
https://doi.org/10.1002/cam4.3570 |
| [14] | Chen, J., Liu, X., Xu, Y., Zhang, K., Huang, J., Pan, B., Chen, D., Cui, S., Song, H., Wang, R., Chu, X., Zhu, X. and Chen, L. (2019) TFAP2C-Activated MALAT1 Modulates the Chemo-resistance of Docetaxel-Resistant Lung Adenocarcinoma Cells. Molecular Therapy Nucleic Acids, 14, 567-582. https://doi.org/10.1016/j.omtn.2019.01.005 |
| [15] | Zhou, Q., Liu, L., Zhou, J., Chen, Y., Xie, D., Yao, Y. and Cui, D. (2021) Novel Insights into MALAT1 Function as a MicroRNA Sponge in NSCLC. Frontiers in Oncology, 11, Article 758653. https://doi.org/10.3389/fonc.2021.758653 |
| [16] | Chen, W., Zhao, W., Chen, S., Zhang, L., Guo, Z., Wang, L., Wang, J., Wan, Z., Hong, Y. and Yu, L. (2018) Expression and Correlation of MALAT1 and SOX9 in Non-Small Cell Lung Cancer. The Clinical Respiratory Journal, 12, 2284-2291.
https://doi.org/10.1111/crj.12906 |
| [17] | Esfandi, F., Taheri, M., Omrani, M.D., Shadmehr, M.B., Arsang-Jang, S., Shams, R. and Ghafouri-Fard, S. (2019) Expression of Long Non-Coding RNAs (lncRNAs) Has Been Dysregulated in Non-Small Cell Lung Cancer Tissues. BMC Cancer, 19, Article No. 222. https://doi.org/10.1186/s12885-019-5435-5 |
| [18] | Pan, Y., Liu, L., Cheng, Y., Yu, J. and Feng, Y. (2020) Amplified LncRNA PVT1 Promotes Lung Cancer Proliferation and Metastasis by Facilitating VEGFC Expression. Biochemistry and Cell Biology, 98, 676-682.
https://doi.org/10.1139/bcb-2019-0435 |
| [19] | Xiao, M., Feng, Y., Liu, C. and Zhang, Z. (2018) Prognostic Values of Long Noncoding RNA PVT1 in Various Carcinomas: An Updated Systematic Review and Meta-Analysis. Cell Prolifer-ation, 51, e12519.
https://doi.org/10.1111/cpr.12519 |
| [20] | 李靖凯, 王伟, 周冬冬. LncRNA PVT1在非小细胞肺癌中的表达及与铂类化疗敏感性的关系[J]. 热带医学杂志, 2021, 21(4): 472-476. |
| [21] | Xin, Y., Li, Z., Zheng, H., Chan, M.T.V., Ka Kei Wu, W. (2017) CCAT2: A Novel Oncogenic Long Non-Coding RNA in Human Cancers. Cell Proliferation, 50, e12342. https://doi.org/10.1111/cpr.12342 |
| [22] | Yu, W.L., Yao, J.J., Xie, Z.Z., Huang, Y.J. and Xiao, S. (2021) LncRNA PRNCR1 rs1456315 and CCAT2 rs6983267 Polymorphisms on 8q24 Associated with Lung Cancer. Interna-tional Journal of General Medicine, 14, 255-266.
https://doi.org/10.2147/IJGM.S290997 |
| [23] | He, L., Du, Z.D., Wang, Y., Meng, R.Q. and Zhao, W.W. (2020) Ef-fects of shRNA on Cisplatin-Resistant Non-Small Cell Lung Cancer Cell A549 via Silencing CCAT2. Journal of Si-chuan University Medical Science Edition, 51, 312-319. |
| [24] | 芮文秀, 王亮歌. lncRNA CCAT2调控SIRT1蛋白表达激活Wnt/β-catenin通路影响非小细胞肺癌细胞增殖和转[J]. 中国细胞生物学学报, 2021, 43(5): 971-978. |
| [25] | Chen, S., Wu, H., Lv, N., Wang, H., Wang, Y., Tang, Q., Shao, H. and Sun, C. (2016) LncRNA CCAT2 Predicts Poor Prognosis and Regulates Growth and Metastasis in Small Cell Lung Cancer. Biomedicine & Pharma-cotherapy, 82, 583-588. https://doi.org/10.1016/j.biopha.2016.05.017 |
| [26] | Li, X., Lv, F., Li, F., Du, M., Liang, Y., Ju, S., Liu, Z., Wang, B. and Gao, Y. (2020) Long Non Coding RNA H19 Facilitates Small Cell Lung Cancer Tumor-igenesis through miR-140-5p/FGF9 Axis. OncoTargets and Therapy, 13, 3525-3534.
https://doi.org/10.2147/OTT.S245710 |
| [27] | Zhou, Y. and Xia, Q. (2022) LncRNA H19 Promotes Lung Adenocar-cinoma Progression via Binding to Mutant p53 R175H. Cancers, 14, Article 4486. https://doi.org/10.3390/cancers14184486 |
| [28] | 周建英, 刘震天, 胡珍珍, 等. 肺癌组织中长链非编码RNA-H9的表达与患者免疫功能、炎症反应因子及预后的关系[J]. 中国免疫学杂志, 2021, 37(16): 2012-2016. |
| [29] | Ni, W., Yao, S., Zhou, Y., Liu, Y., Huang, P., Zhou, A., Liu, J., Che, L. and Li, J. (2019) Long Noncoding RNA GAS5 Inhibits Progression of Colorectal Cancer by Interacting with and Triggering YAP Phosphorylation and Degradation and Is Neg-atively Regulated by the m6A Reader YTHDF3. Molecular Cancer, 18, Article No. 143.
https://doi.org/10.1186/s12943-019-1079-y |
| [30] | Al Mourgi, M., El Askary, A., Gharib, A.F., Alzahrani, R., Ban-jer, H.J., Elsawy, W.H., Al, A.E. and Raafat, N. (2021) Circulating Long Non-Coding RNA GAS5: A Non-Invasive Molecular Marker for Prognosis, Response to Treatment and Survival in Non-Small Cell Lung Cancer. Cancer Investi-gation, 39, 505-513.
https://doi.org/10.1080/07357907.2021.1928167 |
| [31] | Ma, J., Miao, H., Zhang, H., Ren, J., Qu, S., Da, J., Xu, F. and Zhao, H. (2021) LncRNA GAS5 Modulates the Progression of Non-Small Cell Lung Cancer through Repressing miR-221-3p and Up-Regulating IRF2. Diagnostic Pathology, 16, Article No. 46. https://doi.org/10.1186/s13000-021-01108-0 |
| [32] | Zhu, L., Zhou, D., Guo, T., Chen, W., Ding, Y., Li, W., Huang, Y., Huang, J. and Pan, X. (2021) LncRNA GAS5 Inhibits Invasion and Migration of Lung Cancer through Influencing EMT Process. Journal of Cancer, 12, 3291-3298.
https://doi.org/10.7150/jca.56218 |
| [33] | Yang, X., Meng, L., Zhong, Y., Hu, F., Wang, L. and Wang, M. (2021) The Long Intergenic Noncoding RNA GAS5 Reduces Cisplatin-Resistance in Non-Small Cell Lung Cancer through the miR-217/LHPP Axis. Aging, 13, 2864-2884.
https://doi.org/10.18632/aging.202352 |
| [34] | Fu, Y., Liu, L., Zhan, J., Zhan, H. and Qiu, C. (2021) LncRNA GAS5 Expression in Non-Small Cell Lung Cancer Tissues and Its Correlation with Ki67 and EGFR. American Journal of Translational Research, 13, 4900-4907. |
| [35] | Wei, L., Ling, M., Yang, S., Xie, Y., Liu, C. and Yi, W. (2021) Long Noncoding RNA NBAT1 Suppresses Hepatocellular Carcinoma Progression via Competitively Associating with IGF2BP1 and Decreasing c-Myc Expression. Human Cell, 34, 539-549. https://doi.org/10.1007/s13577-020-00464-1 |
| [36] | Yan, J., Huang, W., Huang, X., Xiang, W., Ye, C. and Liu, J. (2018) A Negative Feedback Loop between Long Noncoding RNA NBAT1 and Sox9 Inhibits the Malignant Progres-sion of Gastric Cancer Cells. Bioscience Reports, 38, BSR20180882. https://doi.org/10.1042/BSR20180882 |
| [37] | Zheng, T., Li, D., He, Z., Feng, S. and Zhao, S. (2018) Long Noncod-ing RNA NBAT1 Inhibits Autophagy via Suppression of ATG7 in Non-Small Cell Lung Cancer. American Journal of Cancer Research, 8, 1801-1811. |
| [38] | Lv, D., Bi, Q., Li, Y., Deng, J., Wu, N., Hao, S. and Zhao, M. (2021) Long Non-Coding RNA MEG3 Inhibits Cell Migration and Invasion of Non-Small Cell Lung Cancer Cells by Regulating the miR-21-5p/PTEN Axis. Molecular Medicine Reports, 23, Article No. 191. https://doi.org/10.3892/mmr.2021.11830 |
| [39] | Wang, D.L., Yuan, P. and Tian, J.Y. (2020) Expression of Long Noncoding RNA NBAT1 Is Associated with the Outcome of Patients with Non-Small Cell Lung Cancer. Revista da As-socia？？o Médica Brasileira, 66, 898-903.
https://doi.org/10.1590/1806-9282.66.7.898 |
| [40] | Xue, S., Lu, F., Sun, C., Zhao, J., Zhen, H. and Li, X. (2021) LncRNA ZEB1-AS1 Regulates Hepatocellular Carcinoma Progression by Targeting miR-23c. World Journal of Surgical Oncology, 19, Article No. 121.
https://doi.org/10.1186/s12957-021-02176-8 |
| [41] | Ruan, L., Chen, W., Zhao, X., Fang, N. and Li, T. (2022) Pre-dictive Potentials of ZEB1-AS1 in Colorectal Cancer Prognosis and Their Correlation with Immunotherapy. Journal of Oncology, 2022, Article ID: 1084555.
https://doi.org/10.1155/2022/1084555 |
| [42] | Wang, J., Han, X., Yuan, Y., Gu, H., Liao, X. and Jiang, M. (2022) The Value of Dysregulated LncRNAs on Clinicopathology and Survival in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Frontiers in Genetics, 13, Article 821675. https://doi.org/10.3389/fgene.2022.821675 |
| [43] | Jin, J., Wang, H., Si, J., Ni, R., Liu, Y. and Wang, J. (2019) ZEB1-AS1 Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer and Influences Cell Migration and Apoptosis by Repressing ID1. Clinical Science, 133, 381-392.
https://doi.org/10.1042/CS20180983 |
| [44] | Xie, J., Wu, Y., Bian, X., Chen, D., Gui, Q. and Huang, J. (2018) In-creased Expression of lncRNA ZEB1-AS1 in Non-Small Cell Lung Cancer Is Associated with Poor Prognosis. Interna-tional Journal of Clinical and Experimental Pathology, 11, 3703-3707. |
| [45] | Xin, X., Li, Q., Fang, J. and Zhao, T. (2021) LncRNA HOTAIR: A Potential Prognostic Factor and Therapeutic Target in Human Cancers. Frontiers in On-cology, 11, Article 679244. https://doi.org/10.3389/fonc.2021.679244 |
| [46] | Li, S., Xiong, Q., Chen, M., Wang, B., Yang, X., Yang, M., Wang, Q., Cui, Z. and Ge, F. (2021) Long Noncoding RNA HOTAIR Interacts with Y-Box Pro-tein-1 (YBX1) to Regulate Cell Proliferation. Life Science Alliance, 4, e202101139.
https://doi.org/10.26508/lsa.202101139 |
| [47] | Zhang, C., Xu, L., Deng, G., Ding, Y., Bi, K., Jin, H., Shu, J., Yang, J., Deng, H., Wang, Z. and Wang, Y. (2020) Exosomal HOTAIR Promotes Proliferation, Migration and Invasion of Lung Cancer by Sponging miR-203. Science China Life Sciences, 63, 1265-1268. https://doi.org/10.1007/s11427-019-1579-x |
| [48] | Chen, L., Huang, S., Huang, J., Chen, Q. and Zhuang, Q. (2021) Role and Mechanism of Exosome-Derived Long Noncoding RNA HOTAIR in Lung Cancer. ACS Omega, 6, 17217-17227. https://doi.org/10.1021/acsomega.1c00905 |
