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肥胖引发心血管疾病的相关机制研究进展
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Abstract:
肥胖(obesity)易引发心血管疾病(CVD)，会增加CVD患者的发病率、反复住院等风险，且与CVD患者死亡率的升高独立相关。研究显示，肥胖引起的局部或全身性生理病理变化，如慢性炎症反应、脂肪组织释放脂肪因子、血流动力学变化、心脏形态和心室功能的改变以及胰岛素抵抗(IR)等可能是导致CVD疾病发生的相关机制。研究肥胖引发各类CVD的具体机制，可以早期评估和干预肥胖人群中潜在的CVD患者，从而对预防CVD的发生提供帮助。
Obesity is prone to cardiovascular disease (CVD), which increases the morbidity and repeated hos-pitalization of CVD patients, and is independently related to the increase of mortality in CVD pa-tients. Studies have shown that local or systemic physiopathological changes caused by obesity, such as chronic inflammatory response, adipokines released from adipose tissue, hemodynamic changes, changes in cardiac morphology and ventricular function, and insulin resistance (IR) may be related mechanisms for the development of CVD disease. Studying the specific mechanism of obesity causing various types of CVD can help prevent the occurrence of CVD by early evaluation and intervention of potential CVD patients in obese people.
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