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同型半胱氨酸可能引起脑出血的发病机制
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Abstract:
氨酸作为脑出血中的重要的危险因素，其高低与蛛网膜下腔出血的发病率、死亡率及临床康复密切相关，在发病原因各异的蛛网膜下腔出血中各有差异，致病机制主要涉及血管内皮损伤、平滑肌细胞增生、凝血及脂肪代谢异常等多个方面。同型半胱氨酸水平受基因型及代谢、年龄、性别、药物等多种因素影响，补充B族维生素及叶酸能显著降低同型半胱氨酸水平，降低高危人群的同型半胱氨酸水平对脑血管病的二级预防具有重要意义。本文针对同型半胱氨酸水平与蛛网膜下腔出血相关性，在脑出血的发病机制中的作用方面进行综述，旨在为脑出血临床预防及治疗提供参考。
Homocysteine, an important risk factor in cerebral hemorrhage, is closely related to morbidity, mortality and clinical recovery of subarachnoid hemorrhage, and varies among different causes of subarachnoid hemorrhage. Its pathogenesis mainly involves vascular endothelial injury, smooth muscle cell proliferation, coagulation and abnormal fat metabolism. Homocysteine levels are influ-enced by genotype and metabolism, age, gender, and medications, etc. Supplementation with B vitamins and folic acid can significantly reduce homocysteine levels, and reducing homocysteine levels in high-risk groups is important for secondary prevention of cerebrovascular disease. This paper reviews the correlation between homocysteine levels and subarachnoid hemorrhage and its role in the pathogenesis of cerebral hemorrhage, with the aim of providing a reference for clinical prevention and treatment of cerebral hemorrhage.
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