甘露聚糖肽胶囊联合308准分子激光治疗成人白癜风的疗效观察
Effect of Mannan Peptide Capsule Combined with 308 Excimer Laser on Adult Vitiligo

目的：探究甘露聚糖肽胶囊联合308准分子激光治疗成人白癜风的疗效及安全性。方法：选取2022年6月1日至2022年12月1日于青岛大学附属医院皮肤科就诊的成年白癜风患者60例，并从每例患者中随机选取身上一处皮损作为观察对象，随机分成对照组(n = 30处)和观察组(n = 30例)。对照组的白癜风患者给予308准分子激光治疗，观察组的白癜风患者给予甘露聚糖肽胶囊联合308准分子激光治疗，在治疗6个月后比较两组患者的白斑面积变化、皮损复色率变化、皮损积分变化及疗效情况，并在治疗过程中观察产生的不良反应。结果：经过6个月治疗后，两组患者的白斑面积均有所减小，皮损积分均较治疗前有所下降，但观察组的白斑减小面积及其皮损积分降低程度较对照组更明显，并且临床疗效优于对照组，其差异有统计学意义(P < 0.05)。两组患者在不同方案的治疗过程中不良反应的发生率差异无统计学意义(P > 0.05)。结论：甘露聚糖肽胶囊联合308准分子激光治疗成人白癜风明显优于仅应用308准分子激光治疗，且无明显的不良反应。
Objective: To investigate the efficacy and safety of mannan peptide capsule combined with 308 ex-cimer laser in the treatment of adult vitiligo. Methods: A total of 60 adult patients with vitiligo who were admitted to the dermatology department of the Affiliated Hospital of Qingdao University from June 1, 2022 to December 1, 2022 were selected, and one lesion of each patient was randomly se-lected as the observation object, and randomly divided into control group (n = 30 lesions) and ob-servation group (n = 30 cases). Vitiligo patients in the control group were treated with 308 excimer laser, while vitiligo patients in the observation group were treated with mannanan peptide capsule combined with 308 excimer laser. After 6 months of treatment, the changes of white spot area, skin recolor rate, skin integral and efficacy were compared between the two groups, and adverse reac-tions were observed during the treatment. Results: After 6 months of treatment, the white spot ar-ea of both groups was reduced, and the skin lesion score was decreased compared with that before treatment. However, the reduction degree of white spot area and skin lesion score of the observa-tion group was more obvious than that of the control group, and the clinical effect was better than that of the control group, the difference was statistically significant (P < 0.05). There was no statis-tical significance in the incidence of adverse reactions between the two groups in different treat-ment regiments (P > 0.05). Conclusion: Mannan peptide capsule combined with 308 excimer laser in the treatment of adult vitiligo is significantly better than 308 excimer laser alone, and there is no obvious adverse reaction.