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CD4+T淋巴细胞在侵袭性肺部真菌感染的研究进展
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Abstract:
威胁生命的侵袭性肺部真菌感染(Invasive pulmonary fungal infection)的发病率正在增加，特别是在免疫功能低下的患者中，成功解决IFD需要多种不同的免疫细胞参与。本文主要综述了人类CD4+T淋巴细胞对IFD主要病原体的免疫反应的证据，以及淋巴细胞群在抗真菌免疫中作用的最新发现和见解，以加深淋巴细胞在抗真菌中作用机制的理解，为改进抗真菌治疗提供新的思路。
The incidence rate of life threatening invasive pulmonary fungal infection is increasing, especially in patients with low immune function. A variety of different immune cells are needed to successfully solve IFD. This article mainly reviews the evidence of the immune response of human CD4+T lym-phocytes to the main pathogens of IFD, as well as the latest findings and insights on the role of lym-phocyte groups in antifungal immunity, in order to deepen the understanding of the mechanism of lymphocytes in antifungal immunity, and provide new ideas for improving antifungal therapy.
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