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甲状腺疾病与乳腺癌关系的研究进展
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Abstract:
近年来甲状腺疾病与乳腺癌的关系一直备受人们关注。由于甲状腺和乳腺这两个腺体都受下丘脑–垂体–腺体轴调控，所以甲状腺疾病和乳腺疾病两者存在某种共同的病因。因此研究两者的关系对于进一步了解肿瘤的生物学行为有着重要的意义，也有助于两种疾病的诊断和临床管理。该研究总结了甲状腺功能减退、自身免疫性甲状腺炎和甲状腺癌等甲状腺疾病在乳腺癌发病中的作用以及相关机制的研究进展。认为甲减可能减低乳腺癌的风险，自身免疫性甲状腺炎通过免疫系统参与乳腺癌的发生发展，甲状腺癌与乳腺癌之间存在双向联系。
In recent years, the relationship between thyroid disease and breast cancer has attracted much at-tention. Because both thyroid gland and mammary gland are regulated by the hypothala-mus-pituitary-ggland axis, thyroid disease and mammary gland disease have some common cause. Therefore, the study of the relationship between the two is of great significance for further under-standing the biological behavior of tumors, as well as for the diagnosis and clinical management of the two diseases. This study summarized the role of thyroid diseases such as hypothyroidism, au-toimmune thyroiditis and thyroid cancer in the pathogenesis of breast cancer and the research progress of related mechanisms. It is believed that hypothyroidism may reduce the risk of breast cancer. Autoimmune thyroiditis participates in the occurrence and development of breast cancer through the immune system. There is a two-way relationship between thyroid cancer and breast cancer.
| [1] | Fama’, F., Sindoni, A., Sun, H., Kim, H.Y., Geraci, G., Colonna, M.R., Mazzeo, C., Brenta, G., Galeano, M., Benvenga, S. and Dionigi, G. (2022) Development of Histologically Verified Thyroid Diseases in Women Operated for Breast Cancer: A Review of the Literature and a Case Series. Journal of Clinical Medicine, 11, Article No. 3154.
https://doi.org/10.3390/jcm11113154 |
| [2] | Turken, O., NarIn, Y., DemIrbas, S., Onde, M.E., Sayan, O., KandemIr, E.G., YaylacI, M. and Ozturk, A. (2003) Breast Cancer in Association with Thyroid Disorders. Breast Cancer Research, 5, Article No. R110.
https://doi.org/10.1186/bcr609 |
| [3] | Zervoudis, S., Iatrakis, G., Markja, A., Tsatsaris, G., Bothou, A., von Tempelhoff, G.F., Balafouta, M. and Tsikouras, P. (2021) Risk Factors of Synchronous Breast and Thyroid Cancer: A Controlled Multicenter Study and Review of the Literature. Materia Socio-Medica, 33, 298-303. https://doi.org/10.5455/msm.2021.33.298-303 |
| [4] | Dobrinja, C., Scomersi, S., Giudici, F., Vallon, G., Lanzaro, A., Troian, M., Bonazza, D., Romano, A., Zanconati, F., de Manzini, N. and Bortul, M. (2019) Association between Benign Thyroid Disease and Breast Cancer: A Single Center Experience. BMC Endocrine Disorders, 19, Article No. 104. https://doi.org/10.1186/s12902-019-0426-8 |
| [5] | Bach, L., Kostev, K., Schiffmann, L. and Kalder, M. (2020) As-sociation between Thyroid Gland Diseases and Breast Cancer: A Case-Control Study. Breast Cancer Research and Treatment, 182, 207-213.
https://doi.org/10.1007/s10549-020-05675-6 |
| [6] | Peixoto, M.S., de Vasconcelos e Souza, A., Andrade, I.S., de Carvalho el Giusbi, C., Coelho Faria, C., Hecht, F., Miranda-Alves, L., Ferreira, A.C.F., Carvalho, D.P. and Fortunato, R.S. (2021) Hypothyroidism Induces Oxidative Stress and DNA Damage in Breast. Endocrine-Related Cancer, 28, 505-519. https://doi.org/10.1530/ERC-21-0010 |
| [7] | Jomova, K. and Valko, M. (2011) Advances in Metal-Induced Oxidative Stress and Human Disease. Toxicology, 283, 65-87. https://doi.org/10.1016/j.tox.2011.03.001 |
| [8] | Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M. and Mazur, M. (2006) Free Radicals, Metals and Antioxidants in Oxidative Stress-Induced Cancer. Chemico-Biological Interactions, 160, 1-40.
https://doi.org/10.1016/j.cbi.2005.12.009 |
| [9] | Falstie-Jensen, A.M., Kj？rsgaard, A., Lorenzen, E.L., Jensen, J.D., Reinertsen, K.V., Dekkers, O.M., Ewertz, M. and Cronin-Fenton, D.P. (2019) Hypothyroidism and the Risk of Breast Cancer Recurrence and All-Cause Mortality—A Danish Population-Based Study. Breast Cancer Research, 21, Article No. 44.
https://doi.org/10.1186/s13058-019-1122-3 |
| [10] | 刘洁, 高静, 柏丁兮, 等. 甲状腺功能减退与乳腺癌发病风险关系Meta分析[J]. 中华肿瘤防治杂志, 2018, 25(13): 911-916. |
| [11] | Pan, X.-F., Ma, Y.-J., Tang, Y., Yu, M.-M., Wang, H. and Fan, Y.-R. (2020) Breast Cancer Populations May Have an Increased Prevalence of Thyroglobulin Anti-body and Thyroid Peroxidase Antibody: A Systematic Review and Meta-Analysis. Breast Cancer, 27, 828-836. https://doi.org/10.1007/s12282-020-01078-z |
| [12] | Baldini, E., Lauro, A., Tripodi, D., Pironi, D., Amabile, M.I., Ferent, I.C., Lori, E., Gagliardi, F., Bellini, M.I., Forte, F., Pacini, P., Cantisani, V., D’Andrea, V., Sorrenti, S. and Ulisse, S. (2022) Thyroid Diseases and Breast Cancer. Journal of Personalized Medicine, 12, Article No. 156. https://doi.org/10.3390/jpm12020156 |
| [13] | Hu, X., Wang, X., Liang, Y., Chen, X., Zhou, S., Fei, W., Yang, Y. and Que, H. (2022) Cancer Risk in Hashimoto’s Thyroiditis: A Systematic Review and Meta-Analysis. Frontiers in Endo-crinology, 13, Article 937871.
https://doi.org/10.3389/fendo.2022.937871 |
| [14] | Giani, C., Fierabracci, P., Bonacci, R., Gigliotti, A., Campani, D., De Negri, F., Cecchetti, D., Martino, E. and Pinchera, A. (1996) Relationship between Breast Cancer and Thyroid Dis-ease: Relevance of Autoimmune Thyroid Disorders in Breast Malignancy. The Journal of Clinical Endocrinology & Me-tabolism, 81, 990-994.
https://doi.org/10.1210/jcem.81.3.8772562 |
| [15] | Dhingra, M., Mahalanobis, S. and Das, A. (2022) Thyroid Recep-tor β Might Be Responsible for Breast Cancer Associated with Hashimoto’s Thyroiditis: A New Insight into Pathogene-sis. Immunologic Research, 70, 441-448.
https://doi.org/10.1007/s12026-022-09288-7 |
| [16] | ？zmen, T., Güllüo？lu, B.M., Yegen, C.？. and Soran, A. (2015) Autoimmune Thyroid Disease and Breast Cancer Prognosis. European Journal of Breast Health, 11, 67-71. https://doi.org/10.5152/tjbh.2015.2462 |
| [17] | Brandt, J., Borgquist, S. and Manjer, J. (2015) Prospectively Measured Thyroid Hormones and Thyroid Peroxidase Antibodies in Relation to Risk of Different Breast Cancer Subgroups: A Malm？ Diet and Cancer Study. Cancer Causes & Control, 26, 1093-1104. https://doi.org/10.1007/s10552-015-0602-8 |
| [18] | Godlewska, M., Arczewska, K.D., Rudzińska, M., ？yczkowska, A., Krasuska, W., Hanusek, K., Ruf, J., Kiedrowski, M. and Czarnocka, B. (2017) Thyroid Peroxidase (TPO) Expressed in Thyroid and Breast Tissues Shows Similar Antigenic Properties. PLOS ONE, 12, e0179066. https://doi.org/10.1371/journal.pone.0179066 |
| [19] | Siriwardhane, T., Krishna, K., Ranganathan, V., Jayaraman, V., Wang, T., Bei, K., Ashman, S., Rajasekaran, K., Rajasekaran, J.J. and Krishnamurthy, H. (2019) Significance of An-ti-TPO as an Early Predictive Marker in Thyroid Disease. Autoimmune Diseases, 2019, Article ID: 1684074. https://doi.org/10.1155/2019/1684074 |
| [20] | Zhang, L., Wu, Y., Liu, F., Fu, L. and Tong, Z. (2016) Characteristics and Survival of Patients with Metachronous or Synchronous Double Primary Malignancies: Breast and Thyroid Cancer. Oncotarget, 7, 52450-52459.
https://doi.org/10.18632/oncotarget.9547 |
| [21] | Huang, N.-S., Chen, X.-X., Wei, W.-J., Mo, M., Chen, J.-Y., Ma, B., Yang, S.-W., Xu, W.-B., Wu, J., Ji, Q.-H., Guo, X.-M., Liu, G.-Y., Shao, Z.-M. and Wang, Y. (2018) Association Between Breast Cancer and Thyroid Cancer: A Study Based on 13 978 Patients with Breast Cancer. Cancer Medicine, 7, 6393-6400. https://doi.org/10.1002/cam4.1856 |
| [22] | Joseph, K.R., Edirimanne, S. and Eslick, G.D. (2015) The Association between Breast Cancer and Thyroid Cancer: A Meta-Analysis. Breast Cancer Research and Treatment, 152, 173-181. https://doi.org/10.1007/s10549-015-3456-6 |
| [23] | Halada, S., Casado-Medrano, V., Baran, J.A., Lee, J., Chinmay, P., Bauer, A.J. and Franco, A.T. (2022) Hormonal Crosstalk between Thyroid and Breast Cancer. Endocri-nology, 163, Article ID: Bqac075.
https://doi.org/10.1210/endocr/bqac075 |
| [24] | Block, G.E., Jensen, E.V. and Polley, T.Z. (1975) The Prediction of Hormonal Dependency of Mammary Cancer. Annals of Surgery, 182, 342-352. https://doi.org/10.1097/00000658-197509000-00017 |
| [25] | Bolf, E.L., Sprague, B.L. and Carr, F.E. (2019) A Link-age between Thyroid and Breast Cancer: A Common Etiology? Cancer Epidemiology, Biomarkers & Prevention, 28, 643-649. https://doi.org/10.1158/1055-9965.EPI-18-0877 |
| [26] | An, J.H., Hwangbo, Y., Ahn, H.Y., Keam, B., Lee, K.E., Han, W., Park, D.J., Park, I.A., Noh, D.Y., Youn, Y.K., Cho, B.Y., Im, S.A. and Park, Y.J. (2015) A Possible Association between Thyroid Cancer and Breast Cancer. Thyroid, 25, 1330-1338. https://doi.org/10.1089/thy.2014.0561 |
| [27] | Pinheiro, M., Drigo, S.A., Tonhosolo, R., Andrade, S.C.S., Marchi, F.A., Jurisica, I., Kowalski, L.P., Achatz, M.I. and Rogatto, S.R. (2017) HABP2 p.G534E Variant in Patients with Fam-ily History of Thyroid and Breast Cancer. Oncotarget, 8, 40896-40905. https://doi.org/10.18632/oncotarget.16639 |
| [28] | Tomsic, J., Fultz, R., Liyanarachchi, S., He, H., Senter, L. and de la Chapelle, A. (2016) HABP2 G534E Variant in Papillary Thyroid Carcinoma. PLOS ONE, 11, e0146315. https://doi.org/10.1371/journal.pone.0146315 |
| [29] | Yang, S.P. and Ngeow, J. (2016) Familial Non-Medullary Thyroid Cancer: Unraveling the Genetic Maze. Endocrine-Related Cancer, 23, R577-R595. https://doi.org/10.1530/ERC-16-0067 |
| [30] | Oh, J.M. and Ahn, B.C. (2021) Molecular Mechanisms of Radioactive Iodine Refractoriness in Differentiated Thyroid Cancer: Impaired Sodium Iodide Symporter (NIS) Expression Owing to Altered Signaling Pathway Activity and Intracellular Localization of NIS. Theranostics, 11, 6251-6277. https://doi.org/10.7150/thno.57689 |
| [31] | Muller, I. and Barrett-Lee, P.J. (2020) The Antigenic Link between Thy-roid Autoimmunity and Breast Cancer. Seminars in Cancer Biology, 64, 122-134. https://doi.org/10.1016/j.semcancer.2019.05.013 |
| [32] | Smyth, P.P. (2016) The Thyroid and Breast Cancer. Current Opinion in Endocrinology & Diabetes and Obesity, 23, 389-393. https://doi.org/10.1097/MED.0000000000000273 |
| [33] | Muller, I., Zhang, L., Giani, C., Dayan, C.M., Ludgate, M.E. and Grennan-Jones, F. (2016) The Sodium Iodide Symporter Is Unlikely to Be a Thyroid/Breast Shared Antigen. Journal of Endocrinological Investigation, 39, 323-331.
https://doi.org/10.1007/s40618-015-0368-6s |
