|
|
抑郁症病因及诊断方法的研究进展
|
Abstract:
抑郁症作为全球21世纪精神卫生工作的重点，病因及发病机制至今仍无定论，本文综述了神经、免疫、内分泌等多种影响抑郁症的致病因素，以及抑郁症的诊断手段，其中脑电超慢涨落图技术及其对抑郁症诊断的辅助作用可作为目前抑郁症研究的新角度被着重阐述。
As the focus of global mental health work in the 21st century, the etiology and pathogenesis of de-pression are still inconclusive. This article reviews the pathogenic factors of depression, such as nerve, immunity, endocrine and so on, and the diagnostic methods of depression. Among them, Encephalofluctuograph Technology and its auxiliary role in the diagnosis of depression can be emphasized as a new angle of depression research.
| [1] | 柴玉慧, 蔡雅文, 缪明星, 等. 外泌体miRNAs在抑郁症中的作用及作为其生物标志物的研究进展[J]. 中国新药杂志, 2021, 30(16): 1466-1470. |
| [2] | Qi, H., Zong, Q.Q., Lok, G.K.I., et al. (2019) Treatment Rate for Major Depressive Disorder in China: A Meta-Analysis of Epidemiological Studies. The Psychiatric Quarterly, 90, 883-895. https://doi.org/10.1007/s11126-019-09666-9 |
| [3] | Xiang, Y.T., Ng, C.H., Yu, X., et al. (2018) Rethinking Pro-gress and Challenges of Mental Health Care in China. World Psychiatry: Official Journal of the World Psychiatric Association (WPA), 17, 231-232.
https://doi.org/10.1002/wps.20500 |
| [4] | Zhao, X., Liu, L., Hu, C., et al. (2017) Necessity and Feasibility of Im-proving Mental Health Services in China: A Systematic Qualitative Review. The International Journal of Health Plan-ning and Management, 32, 363-371.
https://doi.org/10.1002/hpm.2437 |
| [5] | Levinson, A.J., Fitzgerald, P.B., Favalli, G., et al. (2010) Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder. Biological Psychiatry, 67, 458-464. https://doi.org/10.1016/j.biopsych.2009.09.025 |
| [6] | Godfrey, K.E.M., Gardner, A.C., Kwon, S., et al. (2018) Differences in Excitatory and Inhibitory Neurotransmitter Levels between Depressed Patients and Healthy Controls: A Systematic Review and Meta-Analysis. Journal of Psychiatric Research, 105, 33-44. https://doi.org/10.1016/j.jpsychires.2018.08.015 |
| [7] | 苏日娜. 改良电痉挛治疗抑郁症疗效及患者血清C反应蛋白变化[J]. 中国药物与临床, 2021, 21(14): 2490-2491. |
| [8] | Han, Y., Khodr, C.E., Sapru, M.K., et al. (2011) A microRNA Embedded AAV α-Synuclein Gene Silencing Vector for Dopaminergic Neurons. Brain Research, 1386, 15-24. https://doi.org/10.1016/j.brainres.2011.02.041 |
| [9] | Zaaijer, E.R., Van Dijk, L., De Bruin, K., et al. (2015) Effect of Extended-Release Naltrexone on Striatal Dopamine Transporter Availability, Depression and Anhedonia in Heroin-Dependent Patients. Psychopharmacology, 232, 2597- 2607. https://doi.org/10.1007/s00213-015-3891-4 |
| [10] | 翟天柱, 沈宗霖, 许秀峰. 5-羟色胺1A受体及其基因rs6295位点多态性与抑郁症的研究进展[J]. 医学综述, 2018, 24(4): 631-635. |
| [11] | Kinn, A.M., Gr？nli, J., Fiske, E., et al. (2008) A Double Exposure to Social Defeat Induces Sub-Chronic Effects on Sleep and Open Field Behaviour in Rats. Physiology & Behavior, 95, 553-561.
https://doi.org/10.1016/j.physbeh.2008.07.031 |
| [12] | 曹丰睿, 刘丹, 薛娟, 等. 5羟色胺受体-7在抑郁症中的研究进展[J]. 医学与哲学, 2018, 39(14): 58-60, 67. |
| [13] | Kim, J., Ham, S., Hong, H., et al. (2016) Brain Reward Circuits in Morphine Addiction. Molecules and Cells, 39, 645-653. https://doi.org/10.14348/molcells.2016.0137 |
| [14] | 李永丰, 钱召强. 慢性神经痛对中脑腹侧被盖区多巴胺神经元活动水平的影响[J]. 中国疼痛医学杂志, 2018, 24(11): 815-822. |
| [15] | 侯彩兰, 贾福军, 陈佐明, 等. 重性抑郁症患者脑脊液中P物质、神经肽Y、5-羟色胺及去甲肾上腺素含量的研究. 中华精神科杂志, 2005, 38(4): 198-201. |
| [16] | Raison, C.L., Capuron, L. and Miller, A.H. (2006) Cytokines Sing the Blues: Inflammation and the Pathogenesis of Depression. Trends in Immunology, 27, 24-31. https://doi.org/10.1016/j.it.2005.11.006 |
| [17] | Maes, M. (1995) Evidence for an Immune Response in Major De-pression: A Review and Hypothesis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 19, 11-38. https://doi.org/10.1016/0278-5846(94)00101-M |
| [18] | Shah, P.J., Glabus, M.F., Goodwin, G.M., et al. (2002) Chronic, Treatment-Resistant Depression and Right Fronto-Striatal Atrophy. The British Journal of Psychiatry: The Journal of Mental Science, 180, 434-440.
https://doi.org/10.1192/bjp.180.5.434 |
| [19] | Ferrier, I.N. and Thompson, J.M. (2002) Cognitive Impairment in Bi-polar Affective Disorder: Implications for the Bipolar Diathesis. The British Journal of Psychiatry: The Journal of Mental Science, 180, 293-295.
https://doi.org/10.1192/bjp.180.4.293 |
| [20] | Akiyama, T., Koeda, M., Okubo, Y., et al. (2018) Hypofunction of Left Dorsolateral Prefrontal Cortex in Depression during Verbal Fluency Task: A Multi-Channel Near-Infrared Spectroscopy Study. Journal of Affective Disorders, 231, 83-90. https://doi.org/10.1016/j.jad.2018.01.010 |
| [21] | Schecklmann, M., Dresler, T., Beck, S., et al. (2011) Reduced Prefrontal Oxygenation during Object and Spatial Visual Working Memory in Unpolar and Bipolar Depression. Psychiatry Research, 194, 378-384.
https://doi.org/10.1016/j.pscychresns.2011.01.016 |
| [22] | 李瑜, 许扬扬, 夏梦青, 等. 抑郁障碍的眼动指标研究[J]. 上海精神医学, 2016, 28(6): 326-334. |
| [23] | 李佳, 李雷俊, 张晋碚. 抑郁症中枢神经递质功能的脑涨落图分析[J]. 中国神经精神疾病杂志, 2009, 35(4): 219, 227, 245. |
| [24] | 张云淑, 栗克清, 崔利军. 脑电超慢涨落图技术的基本原理及在精神疾病中的应用[J]. 中国健康心理学杂志, 2011, 19(1): 118-120. |
| [25] | 曾远明, 李长清, 胡常林. 脑电超慢涨落图的正常参考值[J]. 现代医药卫生, 2004, 20(15): 1522-1523. |
| [26] | 王援朝. 抑郁症精神分裂症强迫症脑电超慢涨落图分析[J]. 临床神经电生理学杂志, 2006, 15(3): 182-183. |
| [27] | 许维春, 王新瑞, 马德林, 等. 脑电超慢涨落图在抑郁症治疗中的临床应用[J]. 中国行为医学科学, 2008, 17(1): 16-18. |
